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- W2034921728 abstract "Abstract 1. 1.Liver microsomal preparations have been shown to catalyze the stereospecific synthesis of a ribitol phosphate from ribitol and inorganic pyrophosphate (PP i ). 2. 2.The compound formed has been isolated as a lithium or barium salt and identified as d -ribitol 5-phosphate ( l -ribitol 1-phosphate). Thus the enzyme activity is specific for that primary hydroxyl group of ribitol which corresponds, from the viewpoint of the meso C atom at C-3, to that hydroxyl group of glycerol which is similarly phosphorylated to give glycerol 1-phosphate ( d -α-glycerophosphate). 3. 3.The ribitol phosphate produced from ribitol with ATP and the l -ribulokinase of Aerobacter aerogenes has been identified as d -ribitol 5-phosphate. 4. 4.Glucose is a competitive inhibitor for the synthesis of ribitol phosphate by PP i -ribitol phosphotransferase activity, while ribitol inhibits the synthesis of glucose 6-phosphate non-competitively. 5. 5.The hydrolysis of PP i , which proceeds simultaneously with synthetic phosphotransferase activity, is accelerated by ribitol, as by glycerol, whereas it is inhibited greatly by glucose and slightly by ribose. 6. 6.The four pentitols, under identical conditions, serve as acceptors for phosphotransferase activity from PP i at varying rates: d -arabitol > ribitol > l -arabitol > xylitol . 7. 7.In the livers of fasted and alloxan diabetic rats the levels of enzyme activity are greatly elevated over those found in normal fed animals. In vitro the enzyme is activated by pretreatment of microsomal preparations by NH 4 OH or by detergents. These properties, as well as the kinetics of the enzyme reaction, support the conclusion that PP i -ribitol phosphotransferase activity is a property of the same particulate, membrane bound enzyme which is responsible for glucose-6-phosphatase and PP i -glucose (or glycerol) phosphotransferase activities." @default.
- W2034921728 created "2016-06-24" @default.
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- W2034921728 date "1971-12-01" @default.
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- W2034921728 title "Synthesis of d-ribitol 5-phosphate by an inorganic pyrophosphate-ribitol phosphotransferase activity of microsomal glucose-6-phosphatase" @default.
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- W2034921728 doi "https://doi.org/10.1016/0005-2744(71)90250-6" @default.
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