Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034921807> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2034921807 endingPage "166" @default.
- W2034921807 startingPage "161" @default.
- W2034921807 abstract "The nematocide DBCP (1,2-dibromo-3-chloropropane) produced negative results in a specific-locus test for gene-mutation induction in the germline of male (101 × C3H)F 1 mice, most of which were treated with 5 daily intraperitoneal injections of 80 mg/kg (total exposure, 400 mg/kg); a few received lower exposures. For treated spermatogonial stem cells, the finding of 2 mutations among 39 519 offspring — a rate almost identical to the control rate — rules out (at the 5% significance level) an induced mutation frequency greater than 2.0 times the historical control rate. From treated poststem-cell stages, no mutants were found among 6240 offspring, ruling out (at the 5% significance level) a multiple of 8.0 times the control for these cell types. A multiple rearrangement (7 chromosomes involved in 3 translocations) found in one of the mutants probably arose as a postmeiotic event not associated with the DBCP treatment. The fertility of DBCP-treated males was not disturbed, in keeping with the absence of germ-cell toxicity and dominant lethals found by other investigators in these mice, and in contrast to results in certain other species. While the treated (101 × C3H)F 1 mice are Ah -responsive, other findings make it questionable whether biotransformation of DBCP to reactive intermediates is accomplished via the Ah -receptor system." @default.
- W2034921807 created "2016-06-24" @default.
- W2034921807 creator A5004007494 @default.
- W2034921807 creator A5049900586 @default.
- W2034921807 creator A5077272642 @default.
- W2034921807 date "1986-06-01" @default.
- W2034921807 modified "2023-09-26" @default.
- W2034921807 title "Mouse specific-locus test for the induction of heritable gene mutations by dibromochloropropane (DBCP)" @default.
- W2034921807 cites W1496489701 @default.
- W2034921807 cites W1508654405 @default.
- W2034921807 cites W1557037398 @default.
- W2034921807 cites W1577296862 @default.
- W2034921807 cites W1965388986 @default.
- W2034921807 cites W1967051025 @default.
- W2034921807 cites W1986070006 @default.
- W2034921807 cites W2009800598 @default.
- W2034921807 cites W2020203125 @default.
- W2034921807 cites W2026892708 @default.
- W2034921807 cites W2028177703 @default.
- W2034921807 cites W2038180832 @default.
- W2034921807 cites W2039495461 @default.
- W2034921807 cites W2042443565 @default.
- W2034921807 cites W2045467924 @default.
- W2034921807 cites W2058255637 @default.
- W2034921807 cites W2075170499 @default.
- W2034921807 cites W2080466233 @default.
- W2034921807 cites W2105479534 @default.
- W2034921807 cites W2123734454 @default.
- W2034921807 cites W2158370786 @default.
- W2034921807 cites W4247302574 @default.
- W2034921807 doi "https://doi.org/10.1016/0165-1218(86)90030-3" @default.
- W2034921807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3713725" @default.
- W2034921807 hasPublicationYear "1986" @default.
- W2034921807 type Work @default.
- W2034921807 sameAs 2034921807 @default.
- W2034921807 citedByCount "12" @default.
- W2034921807 countsByYear W20349218072012 @default.
- W2034921807 crossrefType "journal-article" @default.
- W2034921807 hasAuthorship W2034921807A5004007494 @default.
- W2034921807 hasAuthorship W2034921807A5049900586 @default.
- W2034921807 hasAuthorship W2034921807A5077272642 @default.
- W2034921807 hasConcept C104317684 @default.
- W2034921807 hasConcept C109825262 @default.
- W2034921807 hasConcept C112672928 @default.
- W2034921807 hasConcept C138626823 @default.
- W2034921807 hasConcept C143065580 @default.
- W2034921807 hasConcept C153911025 @default.
- W2034921807 hasConcept C16685009 @default.
- W2034921807 hasConcept C2779122487 @default.
- W2034921807 hasConcept C2779234561 @default.
- W2034921807 hasConcept C3018957569 @default.
- W2034921807 hasConcept C54355233 @default.
- W2034921807 hasConcept C71924100 @default.
- W2034921807 hasConcept C84597430 @default.
- W2034921807 hasConcept C86803240 @default.
- W2034921807 hasConceptScore W2034921807C104317684 @default.
- W2034921807 hasConceptScore W2034921807C109825262 @default.
- W2034921807 hasConceptScore W2034921807C112672928 @default.
- W2034921807 hasConceptScore W2034921807C138626823 @default.
- W2034921807 hasConceptScore W2034921807C143065580 @default.
- W2034921807 hasConceptScore W2034921807C153911025 @default.
- W2034921807 hasConceptScore W2034921807C16685009 @default.
- W2034921807 hasConceptScore W2034921807C2779122487 @default.
- W2034921807 hasConceptScore W2034921807C2779234561 @default.
- W2034921807 hasConceptScore W2034921807C3018957569 @default.
- W2034921807 hasConceptScore W2034921807C54355233 @default.
- W2034921807 hasConceptScore W2034921807C71924100 @default.
- W2034921807 hasConceptScore W2034921807C84597430 @default.
- W2034921807 hasConceptScore W2034921807C86803240 @default.
- W2034921807 hasIssue "3" @default.
- W2034921807 hasLocation W20349218071 @default.
- W2034921807 hasLocation W20349218072 @default.
- W2034921807 hasOpenAccess W2034921807 @default.
- W2034921807 hasPrimaryLocation W20349218071 @default.
- W2034921807 hasRelatedWork W1507023994 @default.
- W2034921807 hasRelatedWork W1828691184 @default.
- W2034921807 hasRelatedWork W1886625688 @default.
- W2034921807 hasRelatedWork W2028087115 @default.
- W2034921807 hasRelatedWork W2057739827 @default.
- W2034921807 hasRelatedWork W2060958215 @default.
- W2034921807 hasRelatedWork W2104498991 @default.
- W2034921807 hasRelatedWork W2111958127 @default.
- W2034921807 hasRelatedWork W2125348881 @default.
- W2034921807 hasRelatedWork W2148375889 @default.
- W2034921807 hasVolume "170" @default.
- W2034921807 isParatext "false" @default.
- W2034921807 isRetracted "false" @default.
- W2034921807 magId "2034921807" @default.
- W2034921807 workType "article" @default.