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- W2034921833 abstract "Retinal ganglion cell (RGC) loss after optic nerve damage is a hallmark of certain human ophthalmic diseases including ischemic optic neuropathy (ION) and glaucoma. In a rat model of optic nerve transection, in which 80% of RGCs are eliminated within 14 days, caspase-2 was found to be expressed and cleaved (activated) predominantly in RGC. Inhibition of caspase-2 expression by a chemically modified synthetic short interfering ribonucleic acid (siRNA) delivered by intravitreal administration significantly enhanced RGC survival over a period of at least 30 days. This exogenously delivered siRNA could be found in RGC and other types of retinal cells, persisted inside the retina for at least 1 month and mediated sequence-specific RNA interference without inducing an interferon response. Our results indicate that RGC apoptosis induced by optic nerve injury involves activation of caspase-2, and that synthetic siRNAs designed to inhibit expression of caspase-2 represent potential neuroprotective agents for intervention in human diseases involving RGC loss." @default.
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- W2034921833 date "2011-06-16" @default.
- W2034921833 modified "2023-10-16" @default.
- W2034921833 title "Ocular neuroprotection by siRNA targeting caspase-2" @default.
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- W2034921833 cites W2114208662 @default.
- W2034921833 cites W2117185636 @default.
- W2034921833 cites W2127072511 @default.
- W2034921833 cites W2141814195 @default.
- W2034921833 cites W2143305021 @default.
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- W2034921833 doi "https://doi.org/10.1038/cddis.2011.54" @default.
- W2034921833 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3168996" @default.
- W2034921833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21677688" @default.
- W2034921833 hasPublicationYear "2011" @default.
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