Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034932076> ?p ?o ?g. }
- W2034932076 endingPage "47" @default.
- W2034932076 startingPage "39" @default.
- W2034932076 abstract "Rearrangements of the bcr (M-BCR) gene were studied in 100 patients with chronic myelocytic leukemia (CML). To determine the significance of a chimeric gene expression in the progression of CML, we analyzed 43 patients for bcr-ABL chimeric mRNA expression. Both DNA and RNA analyses revealed a possible influence of breakpoint sites in the bcr region on the duration of the chronic phase. Patients with the breakpoint located at about the 1-kb region between BamHI and HindIII in bcr exon 3 (region C2) had a significantly shorter chronic phase (31 months) (p = 0.028) than patients in whom the breakpoint was located in other regions. When the bcr locus was divided into 5' and 3' regions as for the BamHI cleavage site located near the 5' region of bcr exon 3, the chronic phase duration in patients with the 5' site (HindIII-BamHI) and 3' site (BamHI-EcoRI site) was 75 and 38 months, respectively. However, the difference was not statistically significant (p = 0.128). These results suggest that only the breakpoint site at C2 on the bcr locus, rather than breakpoint sites in other regions, has an important role in the progression of CML." @default.
- W2034932076 created "2016-06-24" @default.
- W2034932076 creator A5021775720 @default.
- W2034932076 creator A5036539516 @default.
- W2034932076 creator A5049598540 @default.
- W2034932076 creator A5051535689 @default.
- W2034932076 creator A5052483359 @default.
- W2034932076 date "1993-10-01" @default.
- W2034932076 modified "2023-09-28" @default.
- W2034932076 title "Influence of M-BCR breakpoint sites on the duration of chronic phase in 100 patients with chronic myelocytic leukemia" @default.
- W2034932076 cites W141563885 @default.
- W2034932076 cites W1580788756 @default.
- W2034932076 cites W179304997 @default.
- W2034932076 cites W180549284 @default.
- W2034932076 cites W186063976 @default.
- W2034932076 cites W1971809076 @default.
- W2034932076 cites W1972804480 @default.
- W2034932076 cites W19910863 @default.
- W2034932076 cites W1992844715 @default.
- W2034932076 cites W1994633553 @default.
- W2034932076 cites W1994830891 @default.
- W2034932076 cites W2006518962 @default.
- W2034932076 cites W2019215987 @default.
- W2034932076 cites W2020092689 @default.
- W2034932076 cites W2021452838 @default.
- W2034932076 cites W2023339831 @default.
- W2034932076 cites W2026250491 @default.
- W2034932076 cites W2033903040 @default.
- W2034932076 cites W2034892057 @default.
- W2034932076 cites W2042847256 @default.
- W2034932076 cites W2048500798 @default.
- W2034932076 cites W2053557709 @default.
- W2034932076 cites W2057375535 @default.
- W2034932076 cites W2060333964 @default.
- W2034932076 cites W2063450941 @default.
- W2034932076 cites W2076372887 @default.
- W2034932076 cites W2079930228 @default.
- W2034932076 cites W2085193833 @default.
- W2034932076 cites W2091349362 @default.
- W2034932076 cites W2095941680 @default.
- W2034932076 cites W2140367442 @default.
- W2034932076 cites W2153317550 @default.
- W2034932076 cites W2166719555 @default.
- W2034932076 cites W2243673614 @default.
- W2034932076 cites W2278444922 @default.
- W2034932076 cites W2337411529 @default.
- W2034932076 cites W2339359539 @default.
- W2034932076 cites W2399049008 @default.
- W2034932076 cites W2405724546 @default.
- W2034932076 cites W2410606477 @default.
- W2034932076 cites W2410647492 @default.
- W2034932076 cites W2425555163 @default.
- W2034932076 cites W294399541 @default.
- W2034932076 cites W296964755 @default.
- W2034932076 cites W2415297533 @default.
- W2034932076 doi "https://doi.org/10.1016/0165-4608(93)90129-a" @default.
- W2034932076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8221611" @default.
- W2034932076 hasPublicationYear "1993" @default.
- W2034932076 type Work @default.
- W2034932076 sameAs 2034932076 @default.
- W2034932076 citedByCount "14" @default.
- W2034932076 countsByYear W20349320762012 @default.
- W2034932076 countsByYear W20349320762021 @default.
- W2034932076 crossrefType "journal-article" @default.
- W2034932076 hasAuthorship W2034932076A5021775720 @default.
- W2034932076 hasAuthorship W2034932076A5036539516 @default.
- W2034932076 hasAuthorship W2034932076A5049598540 @default.
- W2034932076 hasAuthorship W2034932076A5051535689 @default.
- W2034932076 hasAuthorship W2034932076A5052483359 @default.
- W2034932076 hasConcept C104317684 @default.
- W2034932076 hasConcept C128319531 @default.
- W2034932076 hasConcept C130123407 @default.
- W2034932076 hasConcept C138626823 @default.
- W2034932076 hasConcept C151292725 @default.
- W2034932076 hasConcept C153911025 @default.
- W2034932076 hasConcept C206936463 @default.
- W2034932076 hasConcept C2778904597 @default.
- W2034932076 hasConcept C36823959 @default.
- W2034932076 hasConcept C42174275 @default.
- W2034932076 hasConcept C43907098 @default.
- W2034932076 hasConcept C54355233 @default.
- W2034932076 hasConcept C84597430 @default.
- W2034932076 hasConcept C86803240 @default.
- W2034932076 hasConceptScore W2034932076C104317684 @default.
- W2034932076 hasConceptScore W2034932076C128319531 @default.
- W2034932076 hasConceptScore W2034932076C130123407 @default.
- W2034932076 hasConceptScore W2034932076C138626823 @default.
- W2034932076 hasConceptScore W2034932076C151292725 @default.
- W2034932076 hasConceptScore W2034932076C153911025 @default.
- W2034932076 hasConceptScore W2034932076C206936463 @default.
- W2034932076 hasConceptScore W2034932076C2778904597 @default.
- W2034932076 hasConceptScore W2034932076C36823959 @default.
- W2034932076 hasConceptScore W2034932076C42174275 @default.
- W2034932076 hasConceptScore W2034932076C43907098 @default.
- W2034932076 hasConceptScore W2034932076C54355233 @default.
- W2034932076 hasConceptScore W2034932076C84597430 @default.
- W2034932076 hasConceptScore W2034932076C86803240 @default.
- W2034932076 hasIssue "1" @default.