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• W2034932339 abstract "We assessed the relationship of insulin resistance with cognitive decline and brain atrophy over two years in early Alzheimer's disease (AD, n=48) and nondemented controls (n=61). Intravenous glucose tolerance tests were conducted at baseline to determine insulin area-under-the-curve (AUC). A standard battery of cognitive tasks and MRI were conducted at baseline and 2-year follow-up. In nondemented controls, higher baseline insulin AUC was associated with 2-year decline in global cognitive performance (beta=-0.36, p=0.005). In early AD, however, higher insulin AUC was associated with less decline in global cognitive performance (beta=0.26, p=0.06), slower global brain atrophy (beta=0.40, p=0.01) and less regional atrophy in the bilateral hippocampi and cingulate cortices. While insulin resistance is associated with cognitive decline in nondemented aging, higher peripheral insulin may have AD-specific benefits or insulin signaling may be affected by systemic physiologic changes associated with AD. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease." @default.
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• W2034932339 date "2012-03-01" @default.
• W2034932339 modified "2023-10-17" @default.
• W2034932339 title "Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging" @default.
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• W2034932339 doi "https://doi.org/10.1016/j.bbadis.2011.06.011" @default.
• W2034932339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3264795" @default.
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