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- W2034939901 abstract "The physical mechanism responsible for accurately partitioning newly replicated Escherichia coli chromosomes into daughter cells remains a mystery. We present a quantitative characterization of the dynamical motion of the origin of replication (oriC) using a large ensemble of trajectories generated by automated complete-cell-cycle imaging. In contrast to the dynamics of chromosome segregation in eukaryotic cells, we find that the motion in this bacterium is dominated by sub-diffusive dynamics before, throughout and after the segregation process rather than processive (ballistic) motion. Instead, to maintain accurate partitioning without processive motion, we find that oriC sub-diffusion is subject to a small diffusional bias (or drift velocity). Prior to oriC replication, we find that the drift velocity profile is analogous to a damped spring with equilibrium position at mid-cell. After two replicated oriC loci are distinguishable, the equilibrium position moves immediately to the quarter-cell positions and stays relatively constant for the remainder of the cell cycle, suggesting the mechanism responsible for maintaining chromosome structure may also be responsible for oriC segregation." @default.
- W2034939901 created "2016-06-24" @default.
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- W2034939901 date "2013-01-01" @default.
- W2034939901 modified "2023-09-28" @default.
- W2034939901 title "The Escherichia Coli Chromosome is segregated by Biased Diffusion" @default.
- W2034939901 doi "https://doi.org/10.1016/j.bpj.2012.11.3242" @default.
- W2034939901 hasPublicationYear "2013" @default.
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