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• W2034942334 abstract "We found that human herpesvirus 8-encoded IL-6 (vIL-6) induced endogenous human IL-6 (huIL-6) secretion from various cell lines (MT-4, THP-1, U937, Raji, and CESS) including patients with multicentric Castleman's disease. Especially, in MT-4 cells, huIL-6 was enhanced with vIL-6 by 30-fold compared with that of control. In addition, reverse transcriptase-polymerase chain reaction confirmed that vIL-6 induced huIL-6 expression in MT-4 cells. Our novel finding of the huIL-6 induction by vIL-6 indicates that vIL-6 may play a significant role in the pathogenesis of HHV-8 associated diseases." @default.
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• W2034942334 date "2000-01-01" @default.
• W2034942334 modified "2023-09-26" @default.
• W2034942334 title "Human herpesvirus 8-encoded interleukin-6 homologue (viral IL-6) induces endogenous human IL-6 secretion" @default.
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• W2034942334 doi "https://doi.org/10.1002/1096-9071(200007)61:3<332::aid-jmv8>3.0.co;2-3" @default.
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