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- W2034946614 abstract "Clinical imaging is indispensable in cell therapy to monitor tissue repair and the fate of transplanted cells. In regenerative medicine, clinical imaging is indispensable for characterizing damaged tissue and for measuring the safety and efficacy of therapy. However, the ability to track the fate and function of transplanted cells with current technologies is limited. Exogenous contrast labels such as nanoparticles give a strong signal in the short term but are unreliable long term. Genetically encoded labels are good both short- and long-term in animals, but in the human setting they raise regulatory issues related to the safety of genomic integration and potential immunogenicity of reporter proteins. Imaging studies in brain, heart and islets share a common set of challenges, including developing novel labeling approaches to improve detection thresholds and early delineation of toxicity and function. Key areas for future research include addressing safety concerns associated with genetic labels and developing methods to follow cell survival, differentiation and integration with host tissue. Imaging may bridge the gap between cell therapies and health outcomes by elucidating mechanisms of action through longitudinal monitoring." @default.
- W2034946614 created "2016-06-24" @default.
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- W2034946614 creator A5077140689 @default.
- W2034946614 creator A5086704382 @default.
- W2034946614 creator A5090418141 @default.
- W2034946614 date "2014-08-01" @default.
- W2034946614 modified "2023-10-16" @default.
- W2034946614 title "Clinical imaging in regenerative medicine" @default.
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