FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034946750> ?p ?o ?g. }

• W2034946750 endingPage "800" @default.
• W2034946750 startingPage "791" @default.
• W2034946750 abstract "BACKGROUND Phosphatase homologue of tensin (PTEN) is the most commonly mutated gene in prostate cancer. Bone morphogenetic proteins (BMPs) are known to promote differentiation and inhibit proliferation. Previously published reports from other organ systems led us to investigate a mechanistic relationship between PTEN and BMP signaling in prostate epithelial cells. METHODS We analyzed growth rate and PTEN expression in E6, BPH-1, and C4-2B prostate epithelial cells treated with BMP-4. We also treated doxacyclin-inducible PTEN-C4-2B cells with BMP-4 and doxacyclin to determine the effect of BMP on growth and PTEN expression in conditions of increasing PTEN expression. We determined the dependency of BMP-mediated growth inhibition via siRNA knockdown of PTEN expression and BMP treatment. We determined PTEN protein stability by determining the effect of BMP-4 on PTEN protein at time points after treatment with cyclohexamide, a translation inhibitor. RESULTS We found that BMP-4 induces PTEN in E6 and BPH-1 cells and reduces proliferation. Knockdown of PTEN attenuated the growth-inhibiting effects of BMP-4 in these cells. BMP-4 had no effect in PTEN-negative C4-2B cells, but doxacyclin-driven PTEN C4-2B cells responded to BMP-4 with enhanced PTEN and growth inhibition. BMP-4 also increased PTEN protein stability. CONCLUSIONS BMP signaling induces PTEN expression and sustains PTEN protein expression resulting in inhibition of prostate epithelial cell growth. These data are the first to identify a mechanistic linkage between BMP signaling and PTEN in the prostate, both of which are independently identified as tumor suppressors and suggest possible coordinate dysregulation in prostate cancer. Prostate 71:791–800, 2011. © 2010 Wiley-Liss, Inc." @default.
• W2034946750 created "2016-06-24" @default.
• W2034946750 creator A5019404737 @default.
• W2034946750 creator A5020183452 @default.
• W2034946750 creator A5041977242 @default.
• W2034946750 creator A5091149781 @default.
• W2034946750 date "2010-11-04" @default.
• W2034946750 modified "2023-10-18" @default.
• W2034946750 title "Regulation of phosphatase homologue of tensin protein expression by bone morphogenetic proteins in prostate epithelial cells" @default.
• W2034946750 cites W1965408398 @default.
• W2034946750 cites W1971230349 @default.
• W2034946750 cites W1973801926 @default.
• W2034946750 cites W1976536646 @default.
• W2034946750 cites W1984418041 @default.
• W2034946750 cites W1995789564 @default.
• W2034946750 cites W1997503905 @default.
• W2034946750 cites W1999800217 @default.
• W2034946750 cites W2007454530 @default.
• W2034946750 cites W2016233862 @default.
• W2034946750 cites W2016996307 @default.
• W2034946750 cites W2021064276 @default.
• W2034946750 cites W2021466588 @default.
• W2034946750 cites W2022926655 @default.
• W2034946750 cites W2029347765 @default.
• W2034946750 cites W2030162723 @default.
• W2034946750 cites W2033996868 @default.
• W2034946750 cites W2037325698 @default.
• W2034946750 cites W2040805114 @default.
• W2034946750 cites W2044505245 @default.
• W2034946750 cites W2058308851 @default.
• W2034946750 cites W2059290265 @default.
• W2034946750 cites W2061491996 @default.
• W2034946750 cites W2070885297 @default.
• W2034946750 cites W2072929879 @default.
• W2034946750 cites W2076220903 @default.
• W2034946750 cites W2095772199 @default.
• W2034946750 cites W2098623945 @default.
• W2034946750 cites W2099551036 @default.
• W2034946750 cites W2100014078 @default.
• W2034946750 cites W2100506995 @default.
• W2034946750 cites W2105981385 @default.
• W2034946750 cites W2129546321 @default.
• W2034946750 cites W2153000202 @default.
• W2034946750 cites W2168478740 @default.
• W2034946750 doi "https://doi.org/10.1002/pros.21295" @default.
• W2034946750 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3043153" @default.
• W2034946750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21456062" @default.
• W2034946750 hasPublicationYear "2010" @default.
• W2034946750 type Work @default.
• W2034946750 sameAs 2034946750 @default.
• W2034946750 citedByCount "5" @default.
• W2034946750 countsByYear W20349467502012 @default.
• W2034946750 countsByYear W20349467502015 @default.
• W2034946750 countsByYear W20349467502018 @default.
• W2034946750 crossrefType "journal-article" @default.
• W2034946750 hasAuthorship W2034946750A5019404737 @default.
• W2034946750 hasAuthorship W2034946750A5020183452 @default.
• W2034946750 hasAuthorship W2034946750A5041977242 @default.
• W2034946750 hasAuthorship W2034946750A5091149781 @default.
• W2034946750 hasBestOaLocation W20349467502 @default.
• W2034946750 hasConcept C104317684 @default.
• W2034946750 hasConcept C121608353 @default.
• W2034946750 hasConcept C126322002 @default.
• W2034946750 hasConcept C173396325 @default.
• W2034946750 hasConcept C185592680 @default.
• W2034946750 hasConcept C202751555 @default.
• W2034946750 hasConcept C2776235491 @default.
• W2034946750 hasConcept C2777609662 @default.
• W2034946750 hasConcept C2779549131 @default.
• W2034946750 hasConcept C2780192828 @default.
• W2034946750 hasConcept C30352789 @default.
• W2034946750 hasConcept C31507581 @default.
• W2034946750 hasConcept C502942594 @default.
• W2034946750 hasConcept C54355233 @default.
• W2034946750 hasConcept C55493867 @default.
• W2034946750 hasConcept C62112901 @default.
• W2034946750 hasConcept C62478195 @default.
• W2034946750 hasConcept C71924100 @default.
• W2034946750 hasConcept C81885089 @default.
• W2034946750 hasConcept C86554907 @default.
• W2034946750 hasConcept C86803240 @default.
• W2034946750 hasConcept C95444343 @default.
• W2034946750 hasConceptScore W2034946750C104317684 @default.
• W2034946750 hasConceptScore W2034946750C121608353 @default.
• W2034946750 hasConceptScore W2034946750C126322002 @default.
• W2034946750 hasConceptScore W2034946750C173396325 @default.
• W2034946750 hasConceptScore W2034946750C185592680 @default.
• W2034946750 hasConceptScore W2034946750C202751555 @default.
• W2034946750 hasConceptScore W2034946750C2776235491 @default.
• W2034946750 hasConceptScore W2034946750C2777609662 @default.
• W2034946750 hasConceptScore W2034946750C2779549131 @default.
• W2034946750 hasConceptScore W2034946750C2780192828 @default.
• W2034946750 hasConceptScore W2034946750C30352789 @default.
• W2034946750 hasConceptScore W2034946750C31507581 @default.
• W2034946750 hasConceptScore W2034946750C502942594 @default.
• W2034946750 hasConceptScore W2034946750C54355233 @default.
• W2034946750 hasConceptScore W2034946750C55493867 @default.
• W2034946750 hasConceptScore W2034946750C62112901 @default.

• next