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- W2034952243 abstract "We developed a nonhuman primate model to study whether pertussis vaccination is able to disrupt Bordetella pertussis colonization and transmission, and demonstrated that baboons vaccinated with the acellular pertussis vaccines (aP) were protected from classic pertussis symptoms (i.e., coughing and leukocytosis) but were highly colonized and transmitted pertussis to contacts in two of two experiments (1). In their letter to the editor, Domenech de Celles et al. question our extrapolation of results from the baboon model to transmission in human populations (2). We agree that these data should not be directly extrapolated to pertussis transmission in humans. Although baboons are >96% genetically similar to humans, there are likely differences in how the species respond to vaccination and infection. We also agree that aP-vaccinated infected people are likely less efficient at transmitting pertussis compared with unvaccinated infected people, although it is not clear to what extent. In our model, the time required for transmission was greater when the infected baboon was aP-vaccinated compared with unvaccinated animals (3). However, in the baboon model, aP did not prevent infection as well as whole-cell vaccine (wP); therefore, it is reasonable to conclude that circulation of B. pertussis will be higher in an aP-vaccinated population than in a wP-vaccinated population." @default.
- W2034952243 created "2016-06-24" @default.
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- W2034952243 date "2014-02-10" @default.
- W2034952243 modified "2023-09-24" @default.
- W2034952243 title "Reply to Domenech de Cellès et al.: Infection and transmission of pertussis in the baboon model" @default.
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- W2034952243 doi "https://doi.org/10.1073/pnas.1324074111" @default.
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