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• W2034952754 abstract "In the present study, a new strategy to link AZT with betulin/betulinic acid (BA) by click chemistry was designed and achieved. This conjugation via a triazole linkage offers a new direction for modification of anti-HIV triterpenes. Click chemistry provides an easy and productive way for linking two molecules, even when one of them is a large natural product. Among the newly synthesized conjugates, compounds 15 and 16 showed potent anti-HIV activity with EC(50) values of 0.067 and 0.10 µM, respectively, which are comparable to that of AZT (EC(50): 0.10 µM) in the same assay." @default.
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• W2034952754 date "2012-04-01" @default.
• W2034952754 modified "2023-10-05" @default.
• W2034952754 title "Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry" @default.
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• W2034952754 doi "https://doi.org/10.1016/j.tetlet.2012.02.022" @default.
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