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• W2034953733 abstract "Objectives . This study aims to investigate the effect of betulinic acid (BA) on myocardial ischemia reperfusion/injury in an open-chest anesthetized rat model. Methods . The model was induced by 30 minutes left anterior descending occlusion followed by 2 hours reperfusion. There are six groups in our present study: sham operation group, ischemia/reperfusion group, low-dosage BA group, medium-dosage BA group, high-dosage BA group, and fosinopril sodium group. Rats in the latter four groups were administrated with BA (50, 100, and 200 mg/kg, i.g.) or fosinopril sodium (10 mg/kg, i.g.) once a day for 7 days before operation, respectively. Rats in the former two groups were given the same volume of vehicle (0.5% CMC-Na, i.g.). During the operation, cardiac function was continuously monitored. Serum LDH and CK were measured with colorimetric assays. The expression of Bcl-2 and Bax and the apoptosis of cardiomyocytes were investigated with western blot and TUNEL assay, respectively. Results . Pretreatment with BA improved cardiac function and attenuated LDH and CK activities compared with IR group. Further investigation demonstrated that the expression of Bcl-2 and Bax and TUNEL assay was in line with the above results. Conclusion . BA may reduce the release of LDH and CK, prevent cardiomyocytes apoptosis, and eventually alleviate the extent of the myocardial ischemia/reperfusion injury." @default.
• W2034953733 created "2016-06-24" @default.
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• W2034953733 date "2014-01-01" @default.
• W2034953733 modified "2023-09-23" @default.
• W2034953733 title "Cardioprotective Effect of Betulinic Acid on Myocardial Ischemia Reperfusion Injury in Rats" @default.
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• W2034953733 doi "https://doi.org/10.1155/2014/573745" @default.
• W2034953733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4055472" @default.
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