Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034956064> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2034956064 abstract "Control of the rate of cellular proliferation in the erythron seems to be mediated by a tissue-specific mitotic inhibitor, termed the erythrocytic chalone. the function of this substance seems to be to prevent excessive proliferation of the erythrocyte precursor cells by means of a negative feedback and in terms of peripheral cell numbers.The erythrocytic chalone is present in mature erythrocytes, from which it can be extracted by incubation in a chemically defined medium. It is also present in fresh normal serum and it is possible that in physiological conditions the factor is continuously liberated from mature erythrocytes into the surrounding plasma.In the rat, in an artificially induced polycythaemia the concentration of the chalone in the serum is increased and this increment appears to be the sole cause of the enhanced inhibitory action of polycythaemic serum on the proliferation of the bone marrow cells in vitro.The mode of action of the erythrocytic chalone seems to be to prevent the erythrocyte precursor cells from entering the generative cell cycle; the chalone thus regulates the production of erythrocytes by changing the ‘proliferation efficiency’ in the erythron.So far, nothing is known about the chemical nature of the erythrocytic chalone. However, in gel filtration it is eluted in the same zone as the granulocytic chalone, its molecular weight thus being about 2000-4000." @default.
- W2034956064 created "2016-06-24" @default.
- W2034956064 creator A5018362815 @default.
- W2034956064 creator A5044938327 @default.
- W2034956064 date "1971-01-01" @default.
- W2034956064 modified "2023-09-23" @default.
- W2034956064 title "ERYTHROCYTIC CHALONE, A TISSUE-SPECIFIC INHIBITOR OF CELL PROLIFERATION IN THE ERYTHRON" @default.
- W2034956064 cites W1543722286 @default.
- W2034956064 cites W2006876229 @default.
- W2034956064 cites W2009264930 @default.
- W2034956064 cites W2018105131 @default.
- W2034956064 cites W2045317574 @default.
- W2034956064 cites W2047764527 @default.
- W2034956064 cites W31117504 @default.
- W2034956064 cites W4254542218 @default.
- W2034956064 doi "https://doi.org/10.1111/j.1365-2184.1971.tb01512.x" @default.
- W2034956064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4256041" @default.
- W2034956064 hasPublicationYear "1971" @default.
- W2034956064 type Work @default.
- W2034956064 sameAs 2034956064 @default.
- W2034956064 citedByCount "16" @default.
- W2034956064 countsByYear W20349560642017 @default.
- W2034956064 crossrefType "journal-article" @default.
- W2034956064 hasAuthorship W2034956064A5018362815 @default.
- W2034956064 hasAuthorship W2034956064A5044938327 @default.
- W2034956064 hasConcept C126322002 @default.
- W2034956064 hasConcept C1491633281 @default.
- W2034956064 hasConcept C185592680 @default.
- W2034956064 hasConcept C202751555 @default.
- W2034956064 hasConcept C203014093 @default.
- W2034956064 hasConcept C25642318 @default.
- W2034956064 hasConcept C2778248108 @default.
- W2034956064 hasConcept C2778740236 @default.
- W2034956064 hasConcept C2779703530 @default.
- W2034956064 hasConcept C2780007613 @default.
- W2034956064 hasConcept C55493867 @default.
- W2034956064 hasConcept C62112901 @default.
- W2034956064 hasConcept C71924100 @default.
- W2034956064 hasConcept C86803240 @default.
- W2034956064 hasConcept C93304396 @default.
- W2034956064 hasConcept C95444343 @default.
- W2034956064 hasConceptScore W2034956064C126322002 @default.
- W2034956064 hasConceptScore W2034956064C1491633281 @default.
- W2034956064 hasConceptScore W2034956064C185592680 @default.
- W2034956064 hasConceptScore W2034956064C202751555 @default.
- W2034956064 hasConceptScore W2034956064C203014093 @default.
- W2034956064 hasConceptScore W2034956064C25642318 @default.
- W2034956064 hasConceptScore W2034956064C2778248108 @default.
- W2034956064 hasConceptScore W2034956064C2778740236 @default.
- W2034956064 hasConceptScore W2034956064C2779703530 @default.
- W2034956064 hasConceptScore W2034956064C2780007613 @default.
- W2034956064 hasConceptScore W2034956064C55493867 @default.
- W2034956064 hasConceptScore W2034956064C62112901 @default.
- W2034956064 hasConceptScore W2034956064C71924100 @default.
- W2034956064 hasConceptScore W2034956064C86803240 @default.
- W2034956064 hasConceptScore W2034956064C93304396 @default.
- W2034956064 hasConceptScore W2034956064C95444343 @default.
- W2034956064 hasLocation W20349560641 @default.
- W2034956064 hasLocation W20349560642 @default.
- W2034956064 hasOpenAccess W2034956064 @default.
- W2034956064 hasPrimaryLocation W20349560641 @default.
- W2034956064 hasRelatedWork W2062057385 @default.
- W2034956064 hasRelatedWork W2072529897 @default.
- W2034956064 hasRelatedWork W2083693850 @default.
- W2034956064 hasRelatedWork W2132205889 @default.
- W2034956064 hasRelatedWork W2163491624 @default.
- W2034956064 hasRelatedWork W2408908667 @default.
- W2034956064 hasRelatedWork W2804821088 @default.
- W2034956064 hasRelatedWork W2903463693 @default.
- W2034956064 hasRelatedWork W2999831276 @default.
- W2034956064 hasRelatedWork W3183075330 @default.
- W2034956064 isParatext "false" @default.
- W2034956064 isRetracted "false" @default.
- W2034956064 magId "2034956064" @default.
- W2034956064 workType "article" @default.