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• W2034956084 abstract "The utility of goldfish as test animals for studies of biologic membrane permeation has led to a detailed analysis of the kinetics of drug transfer, in both directions, across goldfish body membranes. Methodology was developed to study permeation solely across gill membranes as well as across the total body surface. 4-Aminoantipyrine was used in the investigation because this drug is neither metabolized nor protein-bound in goldfish. The kinetics of absorption and exsorption was determined under various conditions (across the gills only, across the total body surface, from and to external media of different pH, exsorption after drug injection and after drug absorption). Drug elimination after immersion of fish in 4-aminoantipyrine solution and subsequent transfer into buffer solution was describable by simple first-order kinetics, while data describing the exit of drug from the fish after intraperitoneal injection could be resolved usually into two separate first-order components (leakage from puncture at site of injection and exsorption across body membranes). Drug absorption was found to be first-order with respect to 4-amino-antipyrine. However, under the conditions of most of the experiments (which permitted the maintenance of an essentially constant concentration gradient across the absorbing membranes) drug absorption proceeded by apparent zero-order kinetics. Changes in pH of the external medium had no effect on exsorption kinetics, but had a marked effect on absorption rates. These observations indicate that changes in pH from 4.0 to 7.0 have no significant effect on the permeability characteristics of the biologic membranes as such, but modify drug absorption only by changing the extent of ionization of a weak acid or base. The utility of goldfish as test animals for studies of biologic membrane permeation has led to a detailed analysis of the kinetics of drug transfer, in both directions, across goldfish body membranes. Methodology was developed to study permeation solely across gill membranes as well as across the total body surface. 4-Aminoantipyrine was used in the investigation because this drug is neither metabolized nor protein-bound in goldfish. The kinetics of absorption and exsorption was determined under various conditions (across the gills only, across the total body surface, from and to external media of different pH, exsorption after drug injection and after drug absorption). Drug elimination after immersion of fish in 4-aminoantipyrine solution and subsequent transfer into buffer solution was describable by simple first-order kinetics, while data describing the exit of drug from the fish after intraperitoneal injection could be resolved usually into two separate first-order components (leakage from puncture at site of injection and exsorption across body membranes). Drug absorption was found to be first-order with respect to 4-amino-antipyrine. However, under the conditions of most of the experiments (which permitted the maintenance of an essentially constant concentration gradient across the absorbing membranes) drug absorption proceeded by apparent zero-order kinetics. Changes in pH of the external medium had no effect on exsorption kinetics, but had a marked effect on absorption rates. These observations indicate that changes in pH from 4.0 to 7.0 have no significant effect on the permeability characteristics of the biologic membranes as such, but modify drug absorption only by changing the extent of ionization of a weak acid or base." @default.
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• W2034956084 date "1965-09-01" @default.
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• W2034956084 title "Drug Absorption and Exsorption Kinetics in Goldfish" @default.
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• W2034956084 doi "https://doi.org/10.1002/jps.2600540920" @default.
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