Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034956467> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2034956467 abstract "The elongation factor Tu (EF-Tu) is a member of the translational GTPase superfamily, whose GTPase activity is stimulated by the ribosome. Recently we elucidated the GTPase mechanism of EF-Tu using computer simulations (Ram Prasad et al. PNAS USA, 110, 20509, (2013)) and concluded that His84 of switch II region acts mainly in an indirect way (i. e., it neither acts as a general base nor stabilizes the TS in a major way). Additionally, we also concluded that although the proton transfer step occurs through an additional water molecule it does not constitutes the rate-limiting barrier. These computational predictions are further confirmed by a recent mutational and biochemical study (Maracci et al. PNAS USA, doi:10.1073/pnas.1412676111, (2014)). This work found that a mutation of Asp21 in the P loop also hampers the GTPase activity of EF-Tu. This observation suggested that the catalytic effect is modulated by the nature of amino acid side chain — thus we obtain a support to our proposal of allosteric control by the preorganization of the p-loop. However, in order to identify conclusively the origin of the observed mutational effects, and thereby the actual role of D21 on the GTPase activity of EF-Tu, it is essential to move to a quantitative structure function analysis rather than mere qualitative arguments. Thus, we conducted a computational study aimed at examining and quantifying the molecular origin of the catalytic effect of Asp21 on the GTPase activity of EF-Tu." @default.
- W2034956467 created "2016-06-24" @default.
- W2034956467 creator A5001174955 @default.
- W2034956467 date "2015-01-01" @default.
- W2034956467 modified "2023-09-28" @default.
- W2034956467 title "Ribosome Assisted GTP Hydrolysis by EF-Tu - Mechanism and the Role of Asp21" @default.
- W2034956467 doi "https://doi.org/10.1016/j.bpj.2014.11.2142" @default.
- W2034956467 hasPublicationYear "2015" @default.
- W2034956467 type Work @default.
- W2034956467 sameAs 2034956467 @default.
- W2034956467 citedByCount "0" @default.
- W2034956467 crossrefType "journal-article" @default.
- W2034956467 hasAuthorship W2034956467A5001174955 @default.
- W2034956467 hasBestOaLocation W20349564671 @default.
- W2034956467 hasConcept C104317684 @default.
- W2034956467 hasConcept C118716 @default.
- W2034956467 hasConcept C12554922 @default.
- W2034956467 hasConcept C166342909 @default.
- W2034956467 hasConcept C181199279 @default.
- W2034956467 hasConcept C185592680 @default.
- W2034956467 hasConcept C207332259 @default.
- W2034956467 hasConcept C2777339483 @default.
- W2034956467 hasConcept C55493867 @default.
- W2034956467 hasConcept C67705224 @default.
- W2034956467 hasConcept C71240020 @default.
- W2034956467 hasConcept C75442077 @default.
- W2034956467 hasConcept C86803240 @default.
- W2034956467 hasConcept C88478588 @default.
- W2034956467 hasConceptScore W2034956467C104317684 @default.
- W2034956467 hasConceptScore W2034956467C118716 @default.
- W2034956467 hasConceptScore W2034956467C12554922 @default.
- W2034956467 hasConceptScore W2034956467C166342909 @default.
- W2034956467 hasConceptScore W2034956467C181199279 @default.
- W2034956467 hasConceptScore W2034956467C185592680 @default.
- W2034956467 hasConceptScore W2034956467C207332259 @default.
- W2034956467 hasConceptScore W2034956467C2777339483 @default.
- W2034956467 hasConceptScore W2034956467C55493867 @default.
- W2034956467 hasConceptScore W2034956467C67705224 @default.
- W2034956467 hasConceptScore W2034956467C71240020 @default.
- W2034956467 hasConceptScore W2034956467C75442077 @default.
- W2034956467 hasConceptScore W2034956467C86803240 @default.
- W2034956467 hasConceptScore W2034956467C88478588 @default.
- W2034956467 hasLocation W20349564671 @default.
- W2034956467 hasOpenAccess W2034956467 @default.
- W2034956467 hasPrimaryLocation W20349564671 @default.
- W2034956467 hasRelatedWork W141704660 @default.
- W2034956467 hasRelatedWork W1857770805 @default.
- W2034956467 hasRelatedWork W1903181902 @default.
- W2034956467 hasRelatedWork W2008359458 @default.
- W2034956467 hasRelatedWork W2014424460 @default.
- W2034956467 hasRelatedWork W2025091622 @default.
- W2034956467 hasRelatedWork W2050521259 @default.
- W2034956467 hasRelatedWork W2059121036 @default.
- W2034956467 hasRelatedWork W2071961259 @default.
- W2034956467 hasRelatedWork W2076281349 @default.
- W2034956467 hasRelatedWork W2080400852 @default.
- W2034956467 hasRelatedWork W2080428730 @default.
- W2034956467 hasRelatedWork W2111308816 @default.
- W2034956467 hasRelatedWork W2140789371 @default.
- W2034956467 hasRelatedWork W2530519204 @default.
- W2034956467 hasRelatedWork W264592437 @default.
- W2034956467 hasRelatedWork W2758454547 @default.
- W2034956467 hasRelatedWork W2928741147 @default.
- W2034956467 hasRelatedWork W372883 @default.
- W2034956467 hasRelatedWork W89114292 @default.
- W2034956467 isParatext "false" @default.
- W2034956467 isRetracted "false" @default.
- W2034956467 magId "2034956467" @default.
- W2034956467 workType "article" @default.