FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034961019> ?p ?o ?g. }

• W2034961019 endingPage "229" @default.
• W2034961019 startingPage "221" @default.
• W2034961019 abstract "The demonstration of local complement protein synthesis leads to speculation as to the biological significance of this phenomenon. A narrative review is provided to illuminate several queries. It is difficult to establish a causal role for the locally produced complement because participation of systemic complement cannot be excluded. It is also difficult to discern whether local complement synthesis is a beneficial response to an inflammatory event or whether it promotes tissue damage. Finally, it remains to be seen if the roles of local and systemic complement differ in these respects. Extrahepatic expression of complement components of the activation pathways may provide a rapid response to microbial invasion. Once produced and activated, these proteins evoke a phlogistic response composed of cells and soluble mediators of inflammation. Many cells, not only synthesize complement proteins, but can also be stimulated via their complement receptors. This positive feedback may enhance local immune defense, especially in organs isolated from plasma components. In addition, local environmental factors in different organs may differentially regulate complement synthesis. These factors may include pro-inflammatory molecules and non-immune effectors, such as tissue ischemia/reoxygenation and drugs. Local complement dysregulation due to inhibition of activity of a complement regulatory component was shown to cause disease and restoration of the capacity to regulate the complement pathway restored health. Extrahepatic complement synthesis may also modulate local cellular responses, as to decrease detrimental damage of the inflammatory reaction. The demonstration that complement proteins play a significant role in the clearance of apoptotic cells suggests that local synthesis and activation of complement may contribute not only to tissue damage but also to tissue repair." @default.
• W2034961019 created "2016-06-24" @default.
• W2034961019 creator A5009219744 @default.
• W2034961019 creator A5030879337 @default.
• W2034961019 creator A5073025839 @default.
• W2034961019 date "2001-08-01" @default.
• W2034961019 modified "2023-10-18" @default.
• W2034961019 title "Extrahepatic synthesis of complement proteins in inflammation" @default.
• W2034961019 cites W105115067 @default.
• W2034961019 cites W1513641086 @default.
• W2034961019 cites W1519358455 @default.
• W2034961019 cites W1534123477 @default.
• W2034961019 cites W1541959720 @default.
• W2034961019 cites W1562562544 @default.
• W2034961019 cites W1592101872 @default.
• W2034961019 cites W1615315558 @default.
• W2034961019 cites W1630503232 @default.
• W2034961019 cites W169718174 @default.
• W2034961019 cites W1794064578 @default.
• W2034961019 cites W1839205276 @default.
• W2034961019 cites W1851444414 @default.
• W2034961019 cites W1873050237 @default.
• W2034961019 cites W1964835089 @default.
• W2034961019 cites W1973385000 @default.
• W2034961019 cites W1984509855 @default.
• W2034961019 cites W1990372621 @default.
• W2034961019 cites W1991071771 @default.
• W2034961019 cites W2006149674 @default.
• W2034961019 cites W2008729226 @default.
• W2034961019 cites W2009326258 @default.
• W2034961019 cites W2010094123 @default.
• W2034961019 cites W2013824779 @default.
• W2034961019 cites W2016366526 @default.
• W2034961019 cites W2016859455 @default.
• W2034961019 cites W2018985332 @default.
• W2034961019 cites W2030074507 @default.
• W2034961019 cites W2030489490 @default.
• W2034961019 cites W2032079691 @default.
• W2034961019 cites W2037699401 @default.
• W2034961019 cites W2045904371 @default.
• W2034961019 cites W2051181211 @default.
• W2034961019 cites W2062069007 @default.
• W2034961019 cites W2062804305 @default.
• W2034961019 cites W2066902808 @default.
• W2034961019 cites W2069305908 @default.
• W2034961019 cites W2071177681 @default.
• W2034961019 cites W2083758179 @default.
• W2034961019 cites W2085789847 @default.
• W2034961019 cites W2086167984 @default.
• W2034961019 cites W2086417798 @default.
• W2034961019 cites W2088377622 @default.
• W2034961019 cites W2090327351 @default.
• W2034961019 cites W2090930997 @default.
• W2034961019 cites W2092714210 @default.
• W2034961019 cites W2092785339 @default.
• W2034961019 cites W2092918048 @default.
• W2034961019 cites W2094783740 @default.
• W2034961019 cites W2100976279 @default.
• W2034961019 cites W2102898694 @default.
• W2034961019 cites W2104223335 @default.
• W2034961019 cites W2118111457 @default.
• W2034961019 cites W2118650749 @default.
• W2034961019 cites W2121814265 @default.
• W2034961019 cites W2123412929 @default.
• W2034961019 cites W2125297646 @default.
• W2034961019 cites W2127031305 @default.
• W2034961019 cites W2136948164 @default.
• W2034961019 cites W2138131568 @default.
• W2034961019 cites W2138404517 @default.
• W2034961019 cites W2146103737 @default.
• W2034961019 cites W2146217294 @default.
• W2034961019 cites W2146429955 @default.
• W2034961019 cites W2147698308 @default.
• W2034961019 cites W2153182146 @default.
• W2034961019 cites W2160183347 @default.
• W2034961019 cites W2174093581 @default.
• W2034961019 cites W217713815 @default.
• W2034961019 cites W2185221141 @default.
• W2034961019 cites W2339184887 @default.
• W2034961019 cites W2339597902 @default.
• W2034961019 cites W2340964511 @default.
• W2034961019 cites W2345449810 @default.
• W2034961019 cites W2395567961 @default.
• W2034961019 cites W2406128100 @default.
• W2034961019 cites W2412214518 @default.
• W2034961019 cites W2423337729 @default.
• W2034961019 cites W2471777819 @default.
• W2034961019 cites W2585732487 @default.
• W2034961019 cites W637492389 @default.
• W2034961019 cites W89137955 @default.
• W2034961019 cites W91526211 @default.
• W2034961019 cites W95912110 @default.
• W2034961019 cites W2032637212 @default.
• W2034961019 doi "https://doi.org/10.1016/s0161-5890(01)00044-x" @default.
• W2034961019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11532283" @default.
• W2034961019 hasPublicationYear "2001" @default.
• W2034961019 type Work @default.
• W2034961019 sameAs 2034961019 @default.

• next