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- W2034961583 abstract "806 The purpose of this study was to examine the effect of a 5-HT reuptake inhibitor (Fluoxetine-HCL) on exercise performance during a 90 min time trial at 65% Wattmax. Seven well trained male cyclists (VO2max 68.1 ± 9.5 ml/kg/min) performed three 90 min endurance performance tests at 65% Wattmax. The evening before and the morning of the time trials, the subjects ingested a capsule containing either placebo or 20 mg Fluoxetine-HCL (total 40 mg). The first trial was a placebo test (P1). A double blind, randomised, placebo controlled, cross-over design was used for the two following tests (P2 and FLU). Each test was separated by at least one week. Blood samples were collected via an indwelling venous catheter (at rest, 30 min, 60 min, end, and 10 min recovery). There was no difference in performance time between trials (resp. P1: 93.3 ± 7.4; P2: 87.9 ± 7.1, PR: 88.8 ± 10). As expected all blood parameters (lactate, glucose, FFA, NH3, Catecholamines, GH, ACTH, Cortisol) increased significantly during the tests (p<0.05). During the fluoxetine trial most parameters were slightly lower but only significantly lower for endorphins and prolactin. The results demonstrate that during a 90 min time trial at 65% Wattmax performance is not influenced by a selective serotonin reuptake inhibitor, although some plasma hormones indicate a central effect of the drug." @default.
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- W2034961583 date "1999-05-01" @default.
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- W2034961583 title "TIME TRIAL PERFORMANCE IS NOT INFLUENCED BY A 5-HT REUPTAKE INHIBITOR" @default.
- W2034961583 doi "https://doi.org/10.1097/00005768-199905001-00804" @default.
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