FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034962885> ?p ?o ?g. }

• W2034962885 endingPage "e24361" @default.
• W2034962885 startingPage "e24361" @default.
• W2034962885 abstract "Background Alzheimer's disease (AD) is an age related progressive neurodegenerative disorder. One of the reasons for Alzheimer's neuropathology is the generation of large aggregates of Aß42 that are toxic in nature and induce oxidative stress, aberrant signaling and many other cellular alterations that trigger neuronal cell death. However, the exact mechanisms leading to cell death are not clearly understood. Methodology/Principal Findings We employed a Drosophila eye model of AD to study how Aß42 causes cell death. Misexpression of higher levels of Aß42 in the differentiating photoreceptors of fly retina rapidly induced aberrant cellular phenotypes and cell death. We found that blocking caspase-dependent cell death initially blocked cell death but did not lead to a significant rescue in the adult eye. However, blocking the levels of c-Jun NH (2)-terminal kinase (JNK) signaling pathway significantly rescued the neurodegeneration phenotype of Aß42 misexpression both in eye imaginal disc as well as the adult eye. Misexpression of Aß42 induced transcriptional upregulation of puckered (puc), a downstream target and functional read out of JNK signaling. Moreover, a three-fold increase in phospho-Jun (activated Jun) protein levels was seen in Aß42 retina as compared to the wild-type retina. When we blocked both caspases and JNK signaling simultaneously in the fly retina, the rescue of the neurodegenerative phenotype is comparable to that caused by blocking JNK signaling pathway alone. Conclusions/Significance Our data suggests that (i) accumulation of Aß42 plaques induces JNK signaling in neurons and (ii) induction of JNK contributes to Aß42 mediated cell death. Therefore, inappropriate JNK activation may indeed be relevant to the AD neuropathology, thus making JNK a key target for AD therapies." @default.
• W2034962885 created "2016-06-24" @default.
• W2034962885 creator A5022925239 @default.
• W2034962885 creator A5043507269 @default.
• W2034962885 creator A5044597754 @default.
• W2034962885 creator A5054409959 @default.
• W2034962885 creator A5065536524 @default.
• W2034962885 creator A5067603018 @default.
• W2034962885 creator A5071239555 @default.
• W2034962885 creator A5075742637 @default.
• W2034962885 date "2011-09-14" @default.
• W2034962885 modified "2023-10-16" @default.
• W2034962885 title "Activation of JNK Signaling Mediates Amyloid-ß-Dependent Cell Death" @default.
• W2034962885 cites W1518579223 @default.
• W2034962885 cites W1543220037 @default.
• W2034962885 cites W1596429639 @default.
• W2034962885 cites W1617816798 @default.
• W2034962885 cites W1966002653 @default.
• W2034962885 cites W1966741597 @default.
• W2034962885 cites W1972850054 @default.
• W2034962885 cites W1977284325 @default.
• W2034962885 cites W1979933415 @default.
• W2034962885 cites W1984755213 @default.
• W2034962885 cites W1984925149 @default.
• W2034962885 cites W1990248374 @default.
• W2034962885 cites W1991631964 @default.
• W2034962885 cites W1993790646 @default.
• W2034962885 cites W1998041465 @default.
• W2034962885 cites W1998994319 @default.
• W2034962885 cites W2005534585 @default.
• W2034962885 cites W2007320902 @default.
• W2034962885 cites W2012015663 @default.
• W2034962885 cites W2015363763 @default.
• W2034962885 cites W2023331434 @default.
• W2034962885 cites W2023401728 @default.
• W2034962885 cites W2037401328 @default.
• W2034962885 cites W2039062433 @default.
• W2034962885 cites W2041629876 @default.
• W2034962885 cites W2042696769 @default.
• W2034962885 cites W2043107604 @default.
• W2034962885 cites W2059887321 @default.
• W2034962885 cites W2060841490 @default.
• W2034962885 cites W2063953032 @default.
• W2034962885 cites W2068948616 @default.
• W2034962885 cites W2069496596 @default.
• W2034962885 cites W2073113116 @default.
• W2034962885 cites W2073299257 @default.
• W2034962885 cites W2076162696 @default.
• W2034962885 cites W2079302920 @default.
• W2034962885 cites W2093655143 @default.
• W2034962885 cites W2101625485 @default.
• W2034962885 cites W2103795148 @default.
• W2034962885 cites W2104104103 @default.
• W2034962885 cites W2104531845 @default.
• W2034962885 cites W2109023063 @default.
• W2034962885 cites W2109727228 @default.
• W2034962885 cites W2110367574 @default.
• W2034962885 cites W2110643873 @default.
• W2034962885 cites W2117513966 @default.
• W2034962885 cites W2127292022 @default.
• W2034962885 cites W2135957529 @default.
• W2034962885 cites W2138996824 @default.
• W2034962885 cites W2139587743 @default.
• W2034962885 cites W2147231139 @default.
• W2034962885 cites W2153561150 @default.
• W2034962885 cites W2155309157 @default.
• W2034962885 cites W2171585060 @default.
• W2034962885 cites W2172260318 @default.
• W2034962885 cites W2190291318 @default.
• W2034962885 cites W4291102411 @default.
• W2034962885 cites W4313635391 @default.
• W2034962885 doi "https://doi.org/10.1371/journal.pone.0024361" @default.
• W2034962885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3173392" @default.
• W2034962885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21949710" @default.
• W2034962885 hasPublicationYear "2011" @default.
• W2034962885 type Work @default.
• W2034962885 sameAs 2034962885 @default.
• W2034962885 citedByCount "72" @default.
• W2034962885 countsByYear W20349628852012 @default.
• W2034962885 countsByYear W20349628852013 @default.
• W2034962885 countsByYear W20349628852014 @default.
• W2034962885 countsByYear W20349628852015 @default.
• W2034962885 countsByYear W20349628852016 @default.
• W2034962885 countsByYear W20349628852017 @default.
• W2034962885 countsByYear W20349628852018 @default.
• W2034962885 countsByYear W20349628852019 @default.
• W2034962885 countsByYear W20349628852020 @default.
• W2034962885 countsByYear W20349628852021 @default.
• W2034962885 countsByYear W20349628852022 @default.
• W2034962885 countsByYear W20349628852023 @default.
• W2034962885 crossrefType "journal-article" @default.
• W2034962885 hasAuthorship W2034962885A5022925239 @default.
• W2034962885 hasAuthorship W2034962885A5043507269 @default.
• W2034962885 hasAuthorship W2034962885A5044597754 @default.
• W2034962885 hasAuthorship W2034962885A5054409959 @default.
• W2034962885 hasAuthorship W2034962885A5065536524 @default.
• W2034962885 hasAuthorship W2034962885A5067603018 @default.
• W2034962885 hasAuthorship W2034962885A5071239555 @default.

• next