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• W2034963509 abstract "In type-I vestibular hair cells (VHCs), the mechanisms involved in intracellular calcium homeostasis have not yet been established. In order to investigate the involvement of an Na + -dependent ionic exchanger in the regulation of cytosolic free calcium concentration, we analyzed the effect of the removal of external sodium on the cytosolic concentration of calcium ions ([Ca 2+ ] i ), sodium ions ([Na + ] i ), and protons (pH i ). These concentrations were measured in type-I VHCs isolated from guinea pig labyrinth, using Fura-2, sodium benzofuran isophtalate (SBFI), and 1,4 diacetoxy-2,3 dicyanobenzol (ADB) respectively. Complete replacement of Na + in the superfusion solution with N -methyl- d -glucamine (NMDG + ), reversibly increased [Ca 2+ ] i by 276 ± 89% ( n = 46) and decreased [Na + ] i by 23 ± 6% ( n = 14). Both responses were prevented by removing external Ca 2+ or chelating internal Ca 2+ . This suggests the presence of coupled Ca 2+ and Na + transport. The [Ca 2+ ] i increase evoked by Na + -free solution was reduced by about 55% with the application of amiloride derivatives and was totally abolished in the presence of high [Mg 2+ ] o . No pH i variation was detected during [Na + ] o reduction. In the absence of external K + , the Na + -free solution failed to induce [Ca 2+ ] i increase; the readmission of external K + restored the [Ca 2+ ] i response. These results are consistent with a Na + Ca 2+ exchanger operating in reverse mode. An K + dependence of this exchange is also suggested." @default.
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• W2034963509 date "1995-09-01" @default.
• W2034963509 modified "2023-09-24" @default.
• W2034963509 title "Calcium homeostasis in guinea pig type-I vestibular hair cell: possible involvement of an Na+Ca2+ exchanger" @default.
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• W2034963509 doi "https://doi.org/10.1016/0378-5955(95)00126-2" @default.
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