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- W2034965090 abstract "Activity of parvalbumin-positive hippocampal interneurons is critical for network synchronization but the receptors involved therein have remained largely unknown. Here we report network and behavioral deficits in mice with selective ablation of NMDA receptors in parvalbumin-positive interneurons (NR1(PVCre-/-)). Recordings of local field potentials and unitary neuronal activity in the hippocampal CA1 area revealed altered theta oscillations (5-10 Hz) in freely behaving NR1(PVCre-/-) mice. Moreover, in contrast to controls, in NR1(PVCre-/-) mice the remaining theta rhythm was abolished by the administration of atropine. Gamma oscillations (35-85 Hz) were increased and less modulated by the concurrent theta rhythm in the mutant. Positional firing of pyramidal cells in NR1(PVCre-/-) mice was less spatially and temporally precise. Finally, NR1(PVCre-/-) mice exhibited impaired spatial working as well as spatial short- and long-term recognition memory but showed no deficits in open field exploratory activity and spatial reference learning." @default.
- W2034965090 created "2016-06-24" @default.
- W2034965090 creator A5011577272 @default.
- W2034965090 creator A5049188251 @default.
- W2034965090 creator A5062301717 @default.
- W2034965090 creator A5080488472 @default.
- W2034965090 creator A5086851703 @default.
- W2034965090 date "2010-11-01" @default.
- W2034965090 modified "2023-10-05" @default.
- W2034965090 title "NMDA Receptor Ablation on Parvalbumin-Positive Interneurons Impairs Hippocampal Synchrony, Spatial Representations, and Working Memory" @default.
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- W2034965090 doi "https://doi.org/10.1016/j.neuron.2010.09.017" @default.
- W2034965090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21040854" @default.
- W2034965090 hasPublicationYear "2010" @default.