FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034970437> ?p ?o ?g. }

• W2034970437 endingPage "2706" @default.
• W2034970437 startingPage "2684" @default.
• W2034970437 abstract "In this study, we evaluate the effect of HO-1 upregulation on blood pressure and cardiac function in the new model of infarct spontaneous hypertensive rats (ISHR). Male spontaneous hypertensive rats (SHR) at 13 weeks (n = 40) and age-matched male Wistar (WT) rats (n = 20) were divided into six groups: WT (sham + normal saline (NS)), WT (sham + Co(III) Protoporphyrin IX Chloride (CoPP)), SHR (myocardial infarction (MI) + NS), SHR (MI + CoPP), SHR (MI + CoPP + Tin Mesoporphyrin IX Dichloride (SnMP)), SHR (sham + NS); CoPP 4.5 mg/kg, SnMP 15 mg/kg, for six weeks, one/week, i.p., n = 10/group. At the sixth week, echocardiography (UCG) and hemodynamics were performed. Then, blood samples and heart tissue were collected. Copp treatment in the SHR (MI + CoPP) group lowered blood pressure, decreased infarcted area, restored cardiac function (left ventricular ejection fraction (LVEF), left ventricular fraction shortening (LVFS), +dp/dtmax, (−dp/dtmax)/left ventricular systolic pressure (LVSP)), inhibited cardiac hypertrophy and ventricular enlargement (downregulating left ventricular end-systolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and heart weight/body weight (HW/BW)), lowered serum CRP, IL-6 and Glu levels and increased serum TB, NO and PGI2 levels. Western blot and immunohistochemistry showed that HO-1 expression was elevated in the SHR (MI + CoPP) group, while co-administration with SnMP suppressed the benefit functions mentioned above. In conclusion, HO-1 upregulation can lower blood pressure and improve post-infarct cardiac function in the ISHR model. These functions may be involved in the inhibition of inflammation and the ventricular remodeling process and in the amelioration of glucose metabolism and endothelial dysfunction." @default.
• W2034970437 created "2016-06-24" @default.
• W2034970437 creator A5002163353 @default.
• W2034970437 creator A5004583777 @default.
• W2034970437 creator A5015993155 @default.
• W2034970437 creator A5038308322 @default.
• W2034970437 creator A5048145081 @default.
• W2034970437 creator A5053981602 @default.
• W2034970437 creator A5054279059 @default.
• W2034970437 creator A5071320185 @default.
• W2034970437 date "2013-01-28" @default.
• W2034970437 modified "2023-10-09" @default.
• W2034970437 title "Effects of Heme Oxygenase-1 Upregulation on Blood Pressure and Cardiac Function in an Animal Model of Hypertensive Myocardial Infarction" @default.
• W2034970437 cites W1945078545 @default.
• W2034970437 cites W1964372289 @default.
• W2034970437 cites W1966474872 @default.
• W2034970437 cites W1971642350 @default.
• W2034970437 cites W1975531124 @default.
• W2034970437 cites W1977818185 @default.
• W2034970437 cites W1979363352 @default.
• W2034970437 cites W1980035250 @default.
• W2034970437 cites W1980817059 @default.
• W2034970437 cites W1986471672 @default.
• W2034970437 cites W1992178888 @default.
• W2034970437 cites W2005276690 @default.
• W2034970437 cites W2006898427 @default.
• W2034970437 cites W2007629061 @default.
• W2034970437 cites W2015240109 @default.
• W2034970437 cites W2018341836 @default.
• W2034970437 cites W2021507265 @default.
• W2034970437 cites W2025120711 @default.
• W2034970437 cites W2035210780 @default.
• W2034970437 cites W2039567680 @default.
• W2034970437 cites W2040587225 @default.
• W2034970437 cites W2052867135 @default.
• W2034970437 cites W2054961027 @default.
• W2034970437 cites W2062989569 @default.
• W2034970437 cites W2067197716 @default.
• W2034970437 cites W2078285002 @default.
• W2034970437 cites W2080883999 @default.
• W2034970437 cites W2096693144 @default.
• W2034970437 cites W2099524301 @default.
• W2034970437 cites W2108611039 @default.
• W2034970437 cites W2120705888 @default.
• W2034970437 cites W2128224225 @default.
• W2034970437 cites W2132797221 @default.
• W2034970437 cites W2134186633 @default.
• W2034970437 cites W2149845157 @default.
• W2034970437 cites W2150710355 @default.
• W2034970437 cites W2151107265 @default.
• W2034970437 cites W2151158739 @default.
• W2034970437 cites W2154399723 @default.
• W2034970437 cites W2155252880 @default.
• W2034970437 cites W2155964857 @default.
• W2034970437 cites W2157305452 @default.
• W2034970437 cites W2168945736 @default.
• W2034970437 cites W2171466485 @default.
• W2034970437 cites W2408652742 @default.
• W2034970437 cites W2602487374 @default.
• W2034970437 doi "https://doi.org/10.3390/ijms14022684" @default.
• W2034970437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3588009" @default.
• W2034970437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23358254" @default.
• W2034970437 hasPublicationYear "2013" @default.
• W2034970437 type Work @default.
• W2034970437 sameAs 2034970437 @default.
• W2034970437 citedByCount "37" @default.
• W2034970437 countsByYear W20349704372013 @default.
• W2034970437 countsByYear W20349704372014 @default.
• W2034970437 countsByYear W20349704372015 @default.
• W2034970437 countsByYear W20349704372016 @default.
• W2034970437 countsByYear W20349704372017 @default.
• W2034970437 countsByYear W20349704372018 @default.
• W2034970437 countsByYear W20349704372019 @default.
• W2034970437 countsByYear W20349704372020 @default.
• W2034970437 countsByYear W20349704372021 @default.
• W2034970437 countsByYear W20349704372022 @default.
• W2034970437 countsByYear W20349704372023 @default.
• W2034970437 crossrefType "journal-article" @default.
• W2034970437 hasAuthorship W2034970437A5002163353 @default.
• W2034970437 hasAuthorship W2034970437A5004583777 @default.
• W2034970437 hasAuthorship W2034970437A5015993155 @default.
• W2034970437 hasAuthorship W2034970437A5038308322 @default.
• W2034970437 hasAuthorship W2034970437A5048145081 @default.
• W2034970437 hasAuthorship W2034970437A5053981602 @default.
• W2034970437 hasAuthorship W2034970437A5054279059 @default.
• W2034970437 hasAuthorship W2034970437A5071320185 @default.
• W2034970437 hasBestOaLocation W20349704371 @default.
• W2034970437 hasConcept C104317684 @default.
• W2034970437 hasConcept C111566952 @default.
• W2034970437 hasConcept C126322002 @default.
• W2034970437 hasConcept C127561419 @default.
• W2034970437 hasConcept C134018914 @default.
• W2034970437 hasConcept C164705383 @default.
• W2034970437 hasConcept C178853913 @default.
• W2034970437 hasConcept C181199279 @default.
• W2034970437 hasConcept C185592680 @default.
• W2034970437 hasConcept C26635844 @default.
• W2034970437 hasConcept C2776217839 @default.

• next