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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034973325> ?p ?o ?g. }

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• W2034973325 abstract "Two closely related scaffolds were identified through an uHTS campaign as desirable starting points for the development of Rho-Kinase (ROCK) inhibitors. Here, we describe our hit-to-lead evaluation process which culminated in the rapid discovery of potent leads such as 22 which successfully demonstrated an early in vivo proof of concept for anti-hypertensive activity." @default.
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• W2034973325 date "2010-06-01" @default.
• W2034973325 modified "2023-10-18" @default.
• W2034973325 title "Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account" @default.
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• W2034973325 doi "https://doi.org/10.1016/j.bmcl.2010.04.070" @default.
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