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- W2034973345 abstract "Among the saturated and unsaturated fatty acids studied, stearic and palmitic acids appeared to be the most thrombogenic when included in the hyperlipemic diet of rats, since they markedly predisposed the animals for the production of large, occlusive, endotoxin-initiated thrombosis. Stearic and palmitic acids were also the most atherogenic, since fatty streaks could consistently be observed in the aorta of rats fed diets containing an excess of these fatty acids. Linoleic acid, a non-thrombogenic fatty acid, was the least atherogenic of the present series. When purified triglycerides constituted the source of fat, tristearin and triolein were equally thrombogenic, although tristearin was much more atherogenic. Trica-prylin was neither thrombogenic nor atherogenic. Among the saturated fatty acids used, palmitic acid was the most and caprylic acid (or tricaprylin) the least hyperlipemic, a finding similar to that reported in man. Oleic acid, particularly in its triolein form, did not seem to be hypocholesterolemic. Of the blood tests carried out in the present experiment, none of them, per se, appeared to serve as a perfect indicator of the thrombotic tendency or the degree of atherosclerosis to be expected." @default.
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- W2034973345 date "1968-01-01" @default.
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- W2034973345 title "Thrombogenicity and atherogenicity of dietary fatty acids in rat" @default.
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- W2034973345 doi "https://doi.org/10.1016/s0368-1319(68)80021-3" @default.
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