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• W2034973943 startingPage "485" @default.
• W2034973943 abstract "To investigate the effects of conjugated bile acid on bacterial growth and cholyglycine hydrolase activity, Clostridium perfingens from human feces was exposed to varying concentrations of taurine- or glycine-conjugated chenodeoxycholic acid. Extracellular enzyme activity was determined by deconjugation of radiolabeled taurocholic acid and viable cells were counted after anaerobic culture at 37°C for 24 h. Viable cells were decreased with more than 1.0 mg conjugated chenodeoxycholic acid per mL and there were no viable cells with 10.0 mg of bile acid per mL. Although enzyme activity was decreased according to the bile acid concentration, enzyme activity per bacterium was increased between 1.0 and 4.0 mg/mL. There were no statistically significant differences between the types of conjugation. It was concluded that conjugated bile acids may exert inhibitory effect on bacterial growth and extracellular cholyglycine hydrolase activity in Clostridium perfringens. However, under the physiologic condition in the human intestine, conjugated bile acid might induce production of extracellular cholyglycine hydrolase per bacterium. (Steroids 59:485–489, 1994)" @default.
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• W2034973943 date "1994-08-01" @default.
• W2034973943 modified "2023-10-18" @default.
• W2034973943 title "High concentrations of conjugated bile acids inhibit bacterial growth of Clostridium perfringens and induce its extracellular cholyglycine hydrolase" @default.
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• W2034973943 doi "https://doi.org/10.1016/0039-128x(94)90062-0" @default.
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