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- W2034974436 abstract "Cardiac sarcoidosis is rare but being increasingly recognized because of poor prognosis [ [1] Silverman K.J. Hutchins G.M. Bulkley B.H. Cardiac sarcoidosis: a clinicopathologic study of 84 unselected patients with systemic sarcoidosis. Circulation. 1978; 58: 1204-1211 Crossref PubMed Scopus (755) Google Scholar ]. Steroids are the mainstay of treatment for cardiac sarcoidosis to resolve active myocardial inflammation [ 2 Yazaki Y. Isobe M. Hiroe M. et al. Prognostic determinants of long-term survival in Japanese patients with cardiac sarcoidosis treated with prednisone. Am J Cardiol. 2001; 88: 1006-1010 Abstract Full Text Full Text PDF PubMed Scopus (490) Google Scholar , 3 Chiu C.Z. Nakatani S. Zhang G. et al. Prevention of left ventricular remodeling by long-term corticosteroid therapy in patients with cardiac sarcoidosis. Am J Cardiol. 2005; 95: 143-146 Abstract Full Text Full Text PDF PubMed Scopus (203) Google Scholar ]. Gallium-67 citrate (67Ga) scintigraphy and 18F-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) are used to evaluate the response to steroid treatment [ 4 Ishimaru S. Tsujino I. Takei T. et al. Focal uptake on 18F-fluoro-2-deoxyglucose positron emission tomography images indicates cardiac involvement of sarcoidosis. Eur Heart J. 2005; 26: 1538-1543 Crossref PubMed Scopus (287) Google Scholar , 5 Tadamura E. Yamamuro M. Kubo S. et al. Multimodality imaging of cardiac sarcoidosis before and after steroid therapy. Circulation. 2006; 113: e771-e773 Crossref PubMed Scopus (37) Google Scholar ]. However, it remains unknown whether steroid treatment can completely resolve active myocardial inflammation evaluated by these imaging modalities and whether the resolution of inflammation is associated with an improvement in left ventricular (LV) function. The aim of this study was to determine the efficacy of steroid treatment for resolving inflammation and improving LV function and to elucidate predictors of the functional responder to steroid treatment in patients with cardiac sarcoidosis." @default.
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- W2034974436 date "2014-09-01" @default.
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- W2034974436 title "Reduction of myocardial inflammation with steroid is not necessarily associated with improvement in left ventricular function in patients with cardiac sarcoidosis: Predictors of functional improvement" @default.
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- W2034974436 doi "https://doi.org/10.1016/j.ijcard.2014.07.042" @default.
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