FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034974949> ?p ?o ?g. }

• W2034974949 endingPage "203" @default.
• W2034974949 startingPage "196" @default.
• W2034974949 abstract "Clinical experience with adenovirus vectors has highlighted the need for improved delivery and targeting. Tumour-associated endothelium offers an additional mechanism for enhanced viral uptake into tumours which is accessible for systemic gene delivery. Building on expertise in using polymer ‘stealthed’ viruses for targeting in vivo, adenovirus expressing luciferase (Adluc) was coated with an amino-reactive polymer based on poly [N-(2-hydroxypropyl) methacrylamide] to ablate normal infection pathways. Direct linkage of a monoclonal antibody against E-selectin (MHES) demonstrated E-selectin-specific transduction of tumour necrosis factor-α (TNF-α)-activated endothelial cells. A two-component targeting system using protein G was developed, to provide optimal antibody orientation. We report an enhancement in transduction of TNF-α-activated endothelium in vitro and ex vivo in a human umbilical vein cord model using the MHES antibody. Similarly a virus retargeted using a chimeric P-selectin Glycoprotein Ligand-1-Fc fusion (PSGL-1) protein showed better circulation kinetics and significant uptake into HepG2 xenografts following systemic administration in mice, with 36-fold higher genome copies, compared with non-modified virus. Immunohistochemistry staining of tumour sections from mice treated with PSGL-1-retargeted virus showed a co-localisation of firefly luciferase with CD31 suggesting selective endothelial targeting. Employment of optimal viral modification using protein G will enable exploration and comparison of alternative targeting ligands targeting tumour-associated endothelium." @default.
• W2034974949 created "2016-06-24" @default.
• W2034974949 creator A5016577781 @default.
• W2034974949 creator A5025452500 @default.
• W2034974949 creator A5032131181 @default.
• W2034974949 creator A5040270800 @default.
• W2034974949 creator A5061590219 @default.
• W2034974949 creator A5080682537 @default.
• W2034974949 date "2011-03-01" @default.
• W2034974949 modified "2023-09-27" @default.
• W2034974949 title "Targeting adenovirus gene delivery to activated tumour-associated vasculature via endothelial selectins" @default.
• W2034974949 cites W1558844847 @default.
• W2034974949 cites W1595750307 @default.
• W2034974949 cites W1900819938 @default.
• W2034974949 cites W1965149783 @default.
• W2034974949 cites W1968940607 @default.
• W2034974949 cites W1974600730 @default.
• W2034974949 cites W1979838211 @default.
• W2034974949 cites W1987723433 @default.
• W2034974949 cites W1995291792 @default.
• W2034974949 cites W1999600810 @default.
• W2034974949 cites W2008694035 @default.
• W2034974949 cites W2017614842 @default.
• W2034974949 cites W2026870049 @default.
• W2034974949 cites W2037845050 @default.
• W2034974949 cites W2044776450 @default.
• W2034974949 cites W2047748391 @default.
• W2034974949 cites W2050368156 @default.
• W2034974949 cites W2054435322 @default.
• W2034974949 cites W2055477134 @default.
• W2034974949 cites W2057905142 @default.
• W2034974949 cites W2057910790 @default.
• W2034974949 cites W2061448062 @default.
• W2034974949 cites W2062826915 @default.
• W2034974949 cites W2067056935 @default.
• W2034974949 cites W2079852426 @default.
• W2034974949 cites W2083827148 @default.
• W2034974949 cites W2084671441 @default.
• W2034974949 cites W2093519391 @default.
• W2034974949 cites W2102826458 @default.
• W2034974949 cites W2105005357 @default.
• W2034974949 cites W2116071714 @default.
• W2034974949 cites W2120680479 @default.
• W2034974949 cites W2125263061 @default.
• W2034974949 cites W2147393870 @default.
• W2034974949 cites W2154853039 @default.
• W2034974949 cites W2157453847 @default.
• W2034974949 cites W2158238293 @default.
• W2034974949 cites W2159716826 @default.
• W2034974949 cites W2316811173 @default.
• W2034974949 cites W2321451097 @default.
• W2034974949 doi "https://doi.org/10.1016/j.jconrel.2010.10.011" @default.
• W2034974949 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3071491" @default.
• W2034974949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20965218" @default.
• W2034974949 hasPublicationYear "2011" @default.
• W2034974949 type Work @default.
• W2034974949 sameAs 2034974949 @default.
• W2034974949 citedByCount "28" @default.
• W2034974949 countsByYear W20349749492012 @default.
• W2034974949 countsByYear W20349749492013 @default.
• W2034974949 countsByYear W20349749492014 @default.
• W2034974949 countsByYear W20349749492015 @default.
• W2034974949 countsByYear W20349749492016 @default.
• W2034974949 countsByYear W20349749492017 @default.
• W2034974949 countsByYear W20349749492019 @default.
• W2034974949 countsByYear W20349749492020 @default.
• W2034974949 countsByYear W20349749492022 @default.
• W2034974949 crossrefType "journal-article" @default.
• W2034974949 hasAuthorship W2034974949A5016577781 @default.
• W2034974949 hasAuthorship W2034974949A5025452500 @default.
• W2034974949 hasAuthorship W2034974949A5032131181 @default.
• W2034974949 hasAuthorship W2034974949A5040270800 @default.
• W2034974949 hasAuthorship W2034974949A5061590219 @default.
• W2034974949 hasAuthorship W2034974949A5080682537 @default.
• W2034974949 hasBestOaLocation W20349749491 @default.
• W2034974949 hasConcept C104317684 @default.
• W2034974949 hasConcept C111335760 @default.
• W2034974949 hasConcept C111599444 @default.
• W2034974949 hasConcept C123894998 @default.
• W2034974949 hasConcept C135983454 @default.
• W2034974949 hasConcept C15152581 @default.
• W2034974949 hasConcept C153911025 @default.
• W2034974949 hasConcept C185592680 @default.
• W2034974949 hasConcept C2778939058 @default.
• W2034974949 hasConcept C2780394083 @default.
• W2034974949 hasConcept C32470452 @default.
• W2034974949 hasConcept C40767141 @default.
• W2034974949 hasConcept C502942594 @default.
• W2034974949 hasConcept C54009773 @default.
• W2034974949 hasConcept C54355233 @default.
• W2034974949 hasConcept C55493867 @default.
• W2034974949 hasConcept C81885089 @default.
• W2034974949 hasConcept C86803240 @default.
• W2034974949 hasConceptScore W2034974949C104317684 @default.
• W2034974949 hasConceptScore W2034974949C111335760 @default.
• W2034974949 hasConceptScore W2034974949C111599444 @default.
• W2034974949 hasConceptScore W2034974949C123894998 @default.
• W2034974949 hasConceptScore W2034974949C135983454 @default.

• next