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- W2034978054 abstract "The response of cultivated cells CEC, HKC, HeLa, Hep-2, CAP-M2 and Vero to venoms of Bothrops atrox, Bothrops venezuelae and Crotalus durissus terrificus have been studied. These venoms produce a marked cytopathogenic effect on cultures. The effects obtained in vitro are constant for each venom and each cell type, thus allowing quantitative studies. It was possible to determine the minimum lethal dose and the median lethal dose in tissue culture by using serial dilutions of the venoms. Cells treated with Bothrops venom showed no inhibition of cellular division, whereas Crotalus venom inhibited division. No marked differences were observed between the responses of normal and malignant cells to the action of the snake venoms. These results indicate the possibility of substituting in vitro systems for in vivo studies on laboratory animals, when studying venom effects." @default.
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- W2034978054 date "1972-03-01" @default.
- W2034978054 modified "2023-10-16" @default.
- W2034978054 title "Effects of Crotalus and Bothrops venom on normal and malignant cells cultivated in vitro" @default.
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- W2034978054 doi "https://doi.org/10.1016/0041-0101(72)90241-3" @default.
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