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• W2034981196 abstract "In contrast to naïve CD4 + T cells, memory CD4 + T cells rapidly express high levels of effector cytokines in response to antigen stimulation. The molecular mechanism for this specific behavior is not well understood. The nuclear factor of activated T cells (NFAT) family of transcription factors plays an important role in the transcription of many cytokine genes. Here we show that memory CD4 + T cells rapidly induce NFAT-mediated transcription upon T cell receptor ligation whereas NFAT activation in naïve CD4 + T cells requires longer periods of stimulation. The difference in kinetics correlates with the low levels of NFATc1 and NFATc2 proteins present in naïve CD4 + T cells and their high levels in memory CD4 + T cells. Accordingly, IL-2 expression requires NFAT activation only in memory CD4 + T cells whereas it is NFAT-independent in naïve CD4 + T cells. Thus, the accumulation of NFATc1 and NFATc2 in memory CD4 + T cells represents a previously uncharacterized regulatory mechanism for the induction of early gene expression after antigen stimulation." @default.
• W2034981196 created "2016-06-24" @default.
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• W2034981196 date "2007-04-24" @default.
• W2034981196 modified "2023-10-02" @default.
• W2034981196 title "Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4 ⁺ T cells" @default.
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• W2034981196 doi "https://doi.org/10.1073/pnas.0610442104" @default.
• W2034981196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1855411" @default.
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• W2034981196 hasPublicationYear "2007" @default.
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