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• W2034981387 abstract "Background . Since the FEV1/FVC ratio declines with age, using the fixed ratio of 0.70 leads to overdiagnosis of COPD in older populations and underdiagnosis among young adults. Objective . To evaluate whether discordant obstructive cases (FEV1/FVC < 0.70 but ≥LLN) are a healthy population or have clinical features that would place them at increased risk. Methods . We used post-bronchodilator spirometry data from the population-based Austrian Burden of Obstructive Lung Disease (BOLD) study. Those with post-bronchodilator FEV1/FVC ratio <LLN and <0.70 were defined as concordant obstructive cases . Participants with post-bronchodilator FEV1/FVC ratio ≥LLN but <0.70 were defined as discordant obstructive cases . Results . Discordant obstructive cases were more likely to be older, male and never-smokers. Additionally they had less respiratory symptoms and less severe impairment of FEV1. However, discordant obstructive cases reported significantly more often a diagnosis of heart disease than subjects with normal lung function (27.2% vs 7.3%,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.015</mml:mn></mml:mrow></mml:math>). Conclusion . The clinical profile of discordant obstructive cases includes potentially important comorbid disease." @default.
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• W2034981387 date "2011-01-01" @default.
• W2034981387 modified "2023-09-27" @default.
• W2034981387 title "Subjects with Discordant Airways Obstruction: Lost between Spirometric Definitions of COPD" @default.
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• W2034981387 doi "https://doi.org/10.1155/2011/780215" @default.
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