Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034981520> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2034981520 endingPage "18761" @default.
- W2034981520 startingPage "18756" @default.
- W2034981520 abstract "The selenocysteine Se-conjugates {RSe−Cys, or RSeCH2CH[(NH2)(COOH)]} metabolism catalyzed by pyridoxal 5‘-phosphate (PLP)-dependent β-lyases has been elucidated in the gas-phase at the density functional level. In this study, pyridoxal 5‘-phosphate (PLP)-dependent β-lyases has been modeled by the [(OMe)P(OH)(O)2]- phosphate. It was shown that the reaction RSe−Cys → RSeH + CH2C[(NH2)(COOH)], which is suggested to occur via the β-H elimination, is energetically unfavorable and encounters high activation barriers of 54.0 (54.1), 54.6 (54.6), and 50.7 (50.9) kcal/mol for R = H, Me, and Ph, respectively. The participation of pyridoxal 5‘-phosphate (PLP)-dependent β-lyases significantly facilitates this reaction, and reduces the C3-H2 (or Cβ-Hβ) activation barrier by almost three times, from 50.7 (50.9) kcal/mol to 18.0 (18.1) kcal/mol for R = Ph. Amazingly, the presence of enzyme completely changes the suggested mechanism of the metabolism of selenocysteine Se-conjugates: In the absence of β-lyases the reaction (in general) occurs via the direct β-H-transfer mechanism, whereas with the participation of enzyme it may occur via the indirect β-H-transfer mechanism called the “H-atom relay” mechanism which includes: (a) the β-H atom uptake by enzyme from the RSe−Cys and (b) the delivery of another H atom from the phosphate cofactor to the Se center." @default.
- W2034981520 created "2016-06-24" @default.
- W2034981520 creator A5012743614 @default.
- W2034981520 date "2004-11-09" @default.
- W2034981520 modified "2023-10-10" @default.
- W2034981520 title "Elucidating the Role of the Pyridoxal 5‘-Phosphate (PLP)-Dependent β-Lyases in Selenocysteine Se-Conjugates Metabolism: A Density Functional Study" @default.
- W2034981520 cites W1965137017 @default.
- W2034981520 cites W1981451973 @default.
- W2034981520 cites W1987702006 @default.
- W2034981520 cites W2029867653 @default.
- W2034981520 cites W2037811962 @default.
- W2034981520 cites W2038083805 @default.
- W2034981520 cites W2045858700 @default.
- W2034981520 cites W2081261122 @default.
- W2034981520 cites W2086361244 @default.
- W2034981520 cites W2086957099 @default.
- W2034981520 cites W2095474273 @default.
- W2034981520 cites W2104928760 @default.
- W2034981520 cites W2114836001 @default.
- W2034981520 cites W2161020839 @default.
- W2034981520 cites W4251440173 @default.
- W2034981520 doi "https://doi.org/10.1021/jp046538z" @default.
- W2034981520 hasPublicationYear "2004" @default.
- W2034981520 type Work @default.
- W2034981520 sameAs 2034981520 @default.
- W2034981520 citedByCount "2" @default.
- W2034981520 crossrefType "journal-article" @default.
- W2034981520 hasAuthorship W2034981520A5012743614 @default.
- W2034981520 hasConcept C104317684 @default.
- W2034981520 hasConcept C134306372 @default.
- W2034981520 hasConcept C161790260 @default.
- W2034981520 hasConcept C181199279 @default.
- W2034981520 hasConcept C185592680 @default.
- W2034981520 hasConcept C197336794 @default.
- W2034981520 hasConcept C197957613 @default.
- W2034981520 hasConcept C2776087148 @default.
- W2034981520 hasConcept C2776834122 @default.
- W2034981520 hasConcept C2777132085 @default.
- W2034981520 hasConcept C2779201268 @default.
- W2034981520 hasConcept C2780859938 @default.
- W2034981520 hasConcept C33923547 @default.
- W2034981520 hasConcept C512185932 @default.
- W2034981520 hasConcept C55493867 @default.
- W2034981520 hasConcept C62231903 @default.
- W2034981520 hasConcept C65024703 @default.
- W2034981520 hasConcept C71240020 @default.
- W2034981520 hasConcept C98892162 @default.
- W2034981520 hasConceptScore W2034981520C104317684 @default.
- W2034981520 hasConceptScore W2034981520C134306372 @default.
- W2034981520 hasConceptScore W2034981520C161790260 @default.
- W2034981520 hasConceptScore W2034981520C181199279 @default.
- W2034981520 hasConceptScore W2034981520C185592680 @default.
- W2034981520 hasConceptScore W2034981520C197336794 @default.
- W2034981520 hasConceptScore W2034981520C197957613 @default.
- W2034981520 hasConceptScore W2034981520C2776087148 @default.
- W2034981520 hasConceptScore W2034981520C2776834122 @default.
- W2034981520 hasConceptScore W2034981520C2777132085 @default.
- W2034981520 hasConceptScore W2034981520C2779201268 @default.
- W2034981520 hasConceptScore W2034981520C2780859938 @default.
- W2034981520 hasConceptScore W2034981520C33923547 @default.
- W2034981520 hasConceptScore W2034981520C512185932 @default.
- W2034981520 hasConceptScore W2034981520C55493867 @default.
- W2034981520 hasConceptScore W2034981520C62231903 @default.
- W2034981520 hasConceptScore W2034981520C65024703 @default.
- W2034981520 hasConceptScore W2034981520C71240020 @default.
- W2034981520 hasConceptScore W2034981520C98892162 @default.
- W2034981520 hasIssue "48" @default.
- W2034981520 hasLocation W20349815201 @default.
- W2034981520 hasOpenAccess W2034981520 @default.
- W2034981520 hasPrimaryLocation W20349815201 @default.
- W2034981520 hasRelatedWork W2030985217 @default.
- W2034981520 hasRelatedWork W2032199426 @default.
- W2034981520 hasRelatedWork W2054896917 @default.
- W2034981520 hasRelatedWork W2067421265 @default.
- W2034981520 hasRelatedWork W2134702221 @default.
- W2034981520 hasRelatedWork W2273570181 @default.
- W2034981520 hasRelatedWork W2313555002 @default.
- W2034981520 hasRelatedWork W2409347968 @default.
- W2034981520 hasRelatedWork W2413750031 @default.
- W2034981520 hasRelatedWork W2414394704 @default.
- W2034981520 hasVolume "108" @default.
- W2034981520 isParatext "false" @default.
- W2034981520 isRetracted "false" @default.
- W2034981520 magId "2034981520" @default.
- W2034981520 workType "article" @default.