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• W2034982870 abstract "(R,S)-1 is a potent antimitotic compound. (R)-1·HCl and (S)-1·HCl were synthesized from (R)- and (S)-3-methyladipic acid. Both enantiomers were potent inhibitors of cell proliferation and caused cellular microtubule loss and mitotic arrest. They inhibited purified tubulin assembly and the binding of [3H]colchicine to tubulin, with (S)-1 being about twice as potent. Cytotoxicity against 60 tumor cell lines, however, indicated that the (S)-isomer was 10- to 88-fold more potent than the (R)-isomer." @default.
• W2034982870 created "2016-06-24" @default.
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• W2034982870 date "2011-08-05" @default.
• W2034982870 modified "2023-10-17" @default.
• W2034982870 title "Synthesis and Biological Activities of (<i>R</i>)- and (<i>S</i>)-<i>N</i>-(4-Methoxyphenyl)-<i>N</i>,2,6-trimethyl-6,7-dihydro-5<i>H</i>-cyclopenta[<i>d</i>]pyrimidin-4-aminium Chloride as Potent Cytotoxic Antitubulin Agents" @default.
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• W2034982870 doi "https://doi.org/10.1021/jm2007722" @default.
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