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• W2034983713 abstract "Previous studies have shown that trophozoites of the pathogenic free-living amoebaAcanthamoeba castellaniirapidly lyse a variety of cellsin vitro.However, the role played by cytolitic molecules that may participate in Acanthamoebal cytopathogenicity has yet to be completely elucidated. The aim of this work was to study whether soluble molecules released byA. castellaniitrophozoites could induce cytopathic effect in human epithelial cellsin vitro.The results obtained indicate thatA. castellaniitrophozoites constitutively elaborate and release soluble factors that immediately elicit a cytosolic free-calcium increase in target cells. This phenomenon is induced by low molecular weight amoebic metabolites and depends on a transmembrane influx of extracellular calcium. Morphological changes, cytoskeletal damage, cell death and cytolysis followed the elevation of cytosolic free-calcium levels. Calcium ions are very important for cell homeostasis, in fact, they control the functions of a variety of cellular responses, including secretion, cell proliferation and apoptosis. Our results suggest that the substained elevation of the cytosolic free-calcium in response toA. castellaniimetabolites might play a fundamental role in target cell damage duringAcanthamoebainfections." @default.
• W2034983713 created "2016-06-24" @default.
• W2034983713 creator A5011147943 @default.
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• W2034983713 date "1997-08-01" @default.
• W2034983713 modified "2023-10-16" @default.
• W2034983713 title "Acanthamoeba castellaniimetabolites increase the intracellular calcium level and cause cytotoxicity in Wish cells" @default.
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• W2034983713 doi "https://doi.org/10.1006/mpat.1997.0138" @default.
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