FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034984424> ?p ?o ?g. }

• W2034984424 endingPage "694" @default.
• W2034984424 startingPage "689" @default.
• W2034984424 abstract "The transforming growth factor-beta (TGF-beta) cytokines are important regulators of growth and differentiation in multiple mammalian organ systems. Recent studies suggest that they may play a significant role in the regulation of pancreatic organogenesis. The authors proposed to examine the ontogeny of expression of the TGF-beta cytokine isoforms (TGF-beta1, beta2, and beta3), as well as that of the type II TGF-beta receptor (TbetaRII), in the pancreas. We hypothesized that their patterns of expression might help to clarify the manner in which they influence the development of this organ.Embryos from pregnant CD-1 mice were harvested on gestational days 12.5, 15.5, and 18.5. Microdissection was performed on the embryos to isolate their pancreases. The pancreases were fixed, frozen embedded, and sectioned with a cryostat. Immunohistochemistrywas performed using polyclonal antibodies to TGF-beta1, beta2, and beta3, and TbetaRII.The patterns of expression of TGF-beta1, beta2, and beta3 were similar throughout gestation. They were all present, though weakly, early in the development of the pancreas, in the E12.5 epithelial cells. Their expression persisted and became localized to the acinar cells later in gestation. TbetaRII staining was present in both the E12.5 epithelial cells and the surrounding mesenchyme. As the pancreas developed, TbetaRII became strongly expressed in the ductal epithelial cells with only minimal staining in the acinar and endocrine cells.TGF-betas may play a role in regulating pancreatic organogenesis. Our data suggest that they may be required for the normal development of acini. As in other cell systems, TGF-beta1 may act as a suppressor of pancreatic cellular growth and differentiation. The localization of TbetaRII to the mature ductal epithelium may indicate a need for ongoing regulation of growth and differentiation in the pancreatic ducts beyond the fetal period." @default.
• W2034984424 created "2016-06-24" @default.
• W2034984424 creator A5005728573 @default.
• W2034984424 creator A5012573007 @default.
• W2034984424 creator A5023565483 @default.
• W2034984424 creator A5042591457 @default.
• W2034984424 creator A5044556352 @default.
• W2034984424 creator A5044737124 @default.
• W2034984424 creator A5074127477 @default.
• W2034984424 date "1999-05-01" @default.
• W2034984424 modified "2023-10-16" @default.
• W2034984424 title "The ontogeny of TGF-β1, -β2, -β3, and TGF-β receptor-II expression in the pancreas: Implications for regulation of growth and differentiation" @default.
• W2034984424 cites W1494055834 @default.
• W2034984424 cites W1663371441 @default.
• W2034984424 cites W1958779837 @default.
• W2034984424 cites W1982970462 @default.
• W2034984424 cites W1999179141 @default.
• W2034984424 cites W2022996882 @default.
• W2034984424 cites W2059979075 @default.
• W2034984424 cites W2078780001 @default.
• W2034984424 cites W2085262869 @default.
• W2034984424 cites W2094890932 @default.
• W2034984424 cites W2100522747 @default.
• W2034984424 cites W2103042473 @default.
• W2034984424 cites W2103385168 @default.
• W2034984424 cites W2103600075 @default.
• W2034984424 cites W2114154263 @default.
• W2034984424 cites W2115802523 @default.
• W2034984424 cites W2124430683 @default.
• W2034984424 cites W2128077493 @default.
• W2034984424 cites W2155530993 @default.
• W2034984424 cites W335061608 @default.
• W2034984424 doi "https://doi.org/10.1016/s0022-3468(99)90357-3" @default.
• W2034984424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10359165" @default.
• W2034984424 hasPublicationYear "1999" @default.
• W2034984424 type Work @default.
• W2034984424 sameAs 2034984424 @default.
• W2034984424 citedByCount "32" @default.
• W2034984424 countsByYear W20349844242012 @default.
• W2034984424 countsByYear W20349844242013 @default.
• W2034984424 countsByYear W20349844242014 @default.
• W2034984424 countsByYear W20349844242016 @default.
• W2034984424 countsByYear W20349844242017 @default.
• W2034984424 countsByYear W20349844242018 @default.
• W2034984424 countsByYear W20349844242020 @default.
• W2034984424 countsByYear W20349844242022 @default.
• W2034984424 countsByYear W20349844242023 @default.
• W2034984424 crossrefType "journal-article" @default.
• W2034984424 hasAuthorship W2034984424A5005728573 @default.
• W2034984424 hasAuthorship W2034984424A5012573007 @default.
• W2034984424 hasAuthorship W2034984424A5023565483 @default.
• W2034984424 hasAuthorship W2034984424A5042591457 @default.
• W2034984424 hasAuthorship W2034984424A5044556352 @default.
• W2034984424 hasAuthorship W2034984424A5044737124 @default.
• W2034984424 hasAuthorship W2034984424A5074127477 @default.
• W2034984424 hasBestOaLocation W20349844241 @default.
• W2034984424 hasConcept C103395026 @default.
• W2034984424 hasConcept C111001777 @default.
• W2034984424 hasConcept C118131993 @default.
• W2034984424 hasConcept C125555471 @default.
• W2034984424 hasConcept C126322002 @default.
• W2034984424 hasConcept C134018914 @default.
• W2034984424 hasConcept C170493617 @default.
• W2034984424 hasConcept C196843134 @default.
• W2034984424 hasConcept C2775960820 @default.
• W2034984424 hasConcept C2776340970 @default.
• W2034984424 hasConcept C2778148616 @default.
• W2034984424 hasConcept C2778229498 @default.
• W2034984424 hasConcept C2778764654 @default.
• W2034984424 hasConcept C46699223 @default.
• W2034984424 hasConcept C71315377 @default.
• W2034984424 hasConcept C71924100 @default.
• W2034984424 hasConcept C86803240 @default.
• W2034984424 hasConcept C87313946 @default.
• W2034984424 hasConcept C95444343 @default.
• W2034984424 hasConceptScore W2034984424C103395026 @default.
• W2034984424 hasConceptScore W2034984424C111001777 @default.
• W2034984424 hasConceptScore W2034984424C118131993 @default.
• W2034984424 hasConceptScore W2034984424C125555471 @default.
• W2034984424 hasConceptScore W2034984424C126322002 @default.
• W2034984424 hasConceptScore W2034984424C134018914 @default.
• W2034984424 hasConceptScore W2034984424C170493617 @default.
• W2034984424 hasConceptScore W2034984424C196843134 @default.
• W2034984424 hasConceptScore W2034984424C2775960820 @default.
• W2034984424 hasConceptScore W2034984424C2776340970 @default.
• W2034984424 hasConceptScore W2034984424C2778148616 @default.
• W2034984424 hasConceptScore W2034984424C2778229498 @default.
• W2034984424 hasConceptScore W2034984424C2778764654 @default.
• W2034984424 hasConceptScore W2034984424C46699223 @default.
• W2034984424 hasConceptScore W2034984424C71315377 @default.
• W2034984424 hasConceptScore W2034984424C71924100 @default.
• W2034984424 hasConceptScore W2034984424C86803240 @default.
• W2034984424 hasConceptScore W2034984424C87313946 @default.
• W2034984424 hasConceptScore W2034984424C95444343 @default.
• W2034984424 hasIssue "5" @default.
• W2034984424 hasLocation W20349844241 @default.
• W2034984424 hasLocation W20349844242 @default.
• W2034984424 hasOpenAccess W2034984424 @default.

• next