FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034987048> ?p ?o ?g. }

• W2034987048 endingPage "397" @default.
• W2034987048 startingPage "392" @default.
• W2034987048 abstract "Abstract Smads are cytoplasmic signal transducers of transforming growth factor‐β (TGF‐β) and bone morphogenetic proteins (BMPs). Their relation to fracture healing is unknown. This study examined the temporal protein expression of Smads, together with TGF‐β and BMPs, using immunohistochemistry in a rodent fracture model. Over‐expression of TGF‐β, BMPs‐2, 4, and 7, common‐mediator Smad (Smad4), and receptor‐regulated Smads (Smads1, 2, 3, and 5) versus lower levels of inhibitory Smad (Smad6), were detected at day 3 in osteogenic cells in the thickened periosteum and bone marrow at the fracture sites. At day 10, Smad6 increased dramatically, Smad2, Smad3, and Smad4 remained elevated while Smad1 and Smad5 decreased in the fracture callus. Smad7 was expressed only in vascular endothelial cells. By day 28, when new bone had replaced the fracture callus, all the protein regulators decreased, approaching control levels. During fracture healing, the expression patterns of Smads1 and 5 were similar to that of BMPs‐2 and 7 whereas the expression of Smads2 and 3 was parallel with that of TGF‐β. The Smad family, associated with BMPs and TGF‐β, may play an important role in the early stage of rat fracture healing. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 60: 392–397, 2002; DOI 10.1002/jbm.1289" @default.
• W2034987048 created "2016-06-24" @default.
• W2034987048 creator A5011541220 @default.
• W2034987048 creator A5053438652 @default.
• W2034987048 creator A5068253062 @default.
• W2034987048 creator A5082047323 @default.
• W2034987048 date "2002-02-14" @default.
• W2034987048 modified "2023-10-17" @default.
• W2034987048 title "TGF-β, BMPS, and their signal transducing mediators, Smads, in rat fracture healing" @default.
• W2034987048 cites W1539442102 @default.
• W2034987048 cites W1963712887 @default.
• W2034987048 cites W1979208896 @default.
• W2034987048 cites W1987504060 @default.
• W2034987048 cites W1991110432 @default.
• W2034987048 cites W1993527272 @default.
• W2034987048 cites W1996746494 @default.
• W2034987048 cites W2000939770 @default.
• W2034987048 cites W2001696158 @default.
• W2034987048 cites W2015877043 @default.
• W2034987048 cites W2016327551 @default.
• W2034987048 cites W2022461446 @default.
• W2034987048 cites W2026269197 @default.
• W2034987048 cites W2030032142 @default.
• W2034987048 cites W2033887719 @default.
• W2034987048 cites W2034614189 @default.
• W2034987048 cites W2036734848 @default.
• W2034987048 cites W2047121374 @default.
• W2034987048 cites W2074327271 @default.
• W2034987048 cites W2084820537 @default.
• W2034987048 cites W2101408271 @default.
• W2034987048 cites W2133193835 @default.
• W2034987048 cites W2142932120 @default.
• W2034987048 cites W2162141795 @default.
• W2034987048 cites W2170495797 @default.
• W2034987048 doi "https://doi.org/10.1002/jbm.1289" @default.
• W2034987048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11920662" @default.
• W2034987048 hasPublicationYear "2002" @default.
• W2034987048 type Work @default.
• W2034987048 sameAs 2034987048 @default.
• W2034987048 citedByCount "82" @default.
• W2034987048 countsByYear W20349870482012 @default.
• W2034987048 countsByYear W20349870482013 @default.
• W2034987048 countsByYear W20349870482014 @default.
• W2034987048 countsByYear W20349870482015 @default.
• W2034987048 countsByYear W20349870482016 @default.
• W2034987048 countsByYear W20349870482017 @default.
• W2034987048 countsByYear W20349870482018 @default.
• W2034987048 countsByYear W20349870482019 @default.
• W2034987048 countsByYear W20349870482020 @default.
• W2034987048 countsByYear W20349870482021 @default.
• W2034987048 countsByYear W20349870482022 @default.
• W2034987048 countsByYear W20349870482023 @default.
• W2034987048 crossrefType "journal-article" @default.
• W2034987048 hasAuthorship W2034987048A5011541220 @default.
• W2034987048 hasAuthorship W2034987048A5053438652 @default.
• W2034987048 hasAuthorship W2034987048A5068253062 @default.
• W2034987048 hasAuthorship W2034987048A5082047323 @default.
• W2034987048 hasConcept C104317684 @default.
• W2034987048 hasConcept C105702510 @default.
• W2034987048 hasConcept C118131993 @default.
• W2034987048 hasConcept C126322002 @default.
• W2034987048 hasConcept C134018914 @default.
• W2034987048 hasConcept C203014093 @default.
• W2034987048 hasConcept C204232928 @default.
• W2034987048 hasConcept C2777674748 @default.
• W2034987048 hasConcept C2781080636 @default.
• W2034987048 hasConcept C31507581 @default.
• W2034987048 hasConcept C55493867 @default.
• W2034987048 hasConcept C71924100 @default.
• W2034987048 hasConcept C8337478 @default.
• W2034987048 hasConcept C86803240 @default.
• W2034987048 hasConcept C95444343 @default.
• W2034987048 hasConceptScore W2034987048C104317684 @default.
• W2034987048 hasConceptScore W2034987048C105702510 @default.
• W2034987048 hasConceptScore W2034987048C118131993 @default.
• W2034987048 hasConceptScore W2034987048C126322002 @default.
• W2034987048 hasConceptScore W2034987048C134018914 @default.
• W2034987048 hasConceptScore W2034987048C203014093 @default.
• W2034987048 hasConceptScore W2034987048C204232928 @default.
• W2034987048 hasConceptScore W2034987048C2777674748 @default.
• W2034987048 hasConceptScore W2034987048C2781080636 @default.
• W2034987048 hasConceptScore W2034987048C31507581 @default.
• W2034987048 hasConceptScore W2034987048C55493867 @default.
• W2034987048 hasConceptScore W2034987048C71924100 @default.
• W2034987048 hasConceptScore W2034987048C8337478 @default.
• W2034987048 hasConceptScore W2034987048C86803240 @default.
• W2034987048 hasConceptScore W2034987048C95444343 @default.
• W2034987048 hasIssue "3" @default.
• W2034987048 hasLocation W20349870481 @default.
• W2034987048 hasLocation W20349870482 @default.
• W2034987048 hasOpenAccess W2034987048 @default.
• W2034987048 hasPrimaryLocation W20349870481 @default.
• W2034987048 hasRelatedWork W1487086110 @default.
• W2034987048 hasRelatedWork W2002155230 @default.
• W2034987048 hasRelatedWork W2018459525 @default.
• W2034987048 hasRelatedWork W2038559883 @default.
• W2034987048 hasRelatedWork W2082684861 @default.
• W2034987048 hasRelatedWork W2331180226 @default.

• next