FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034987206> ?p ?o ?g. }

• W2034987206 endingPage "492" @default.
• W2034987206 startingPage "481" @default.
• W2034987206 abstract "Examination of the structures of compounds having high affinity for estrogen, progestin, mineralocorticoid and glucocorticoid receptors strongly suggests that receptor binding is primarily the result of a tight association between the receptor and the steroidal A-ring. High affinity binding to the estrogen receptor appears to be dependent upon the presence of a phenolic ring in the substrate. An inverted 1 beta, 2 alpha conformation of the 4-ene-3-one A-ring appears to be most conductive to high affinity binding to the progesterone receptor. Binding to the mineralocorticoid receptor appears to be correlated to a complementary fit between amino acids of the receptor site and a flat 4-en-3-one A-ring similar to that imposed upon aldosterone by the 11,18-epoxide formation. The glucocorticoid receptor appears to prefer a 4-en-3-one A-ring that is bowed toward the alpha-face as is the case in structures having a 9 alpha-fluoro substituent or additional unsaturation at C(1)-C(2). The binding of androgens to their receptor differs in appearing to have an essential dependence upon functional groups at the A- and D-ring end of the steroid. With the exception of the androgens, the data suggest that specific interactions between the steroid B-, C- and D-rings and the receptor play at best a minor role in receptor binding but are the most important factor in determining agonist versus antagonist behavior subsequent to binding. Antagonists that compete for a steroid receptor site may be expected to have the A-ring composition and conformation necessary for receptor binding but lack the 11 beta-OH and the D-ring conformational features and functional groups that induce or stabilize subsequent receptor functions. Antagonists might also be compounds with A-ring conformations appropriate for binding but other structural features that interfere with subsequent receptor functions essential to activity." @default.
• W2034987206 created "2016-06-24" @default.
• W2034987206 creator A5024296656 @default.
• W2034987206 creator A5038075414 @default.
• W2034987206 creator A5050519239 @default.
• W2034987206 creator A5054613179 @default.
• W2034987206 date "1988-10-01" @default.
• W2034987206 modified "2023-10-14" @default.
• W2034987206 title "The mechanism of action of steroid antagonists: Insights from crystallographic studies" @default.
• W2034987206 cites W1508157020 @default.
• W2034987206 cites W1551212779 @default.
• W2034987206 cites W1561941210 @default.
• W2034987206 cites W1584477524 @default.
• W2034987206 cites W1968456747 @default.
• W2034987206 cites W1981959249 @default.
• W2034987206 cites W1985437634 @default.
• W2034987206 cites W1988110363 @default.
• W2034987206 cites W1993818202 @default.
• W2034987206 cites W1997061501 @default.
• W2034987206 cites W1997991108 @default.
• W2034987206 cites W2000609200 @default.
• W2034987206 cites W2001687883 @default.
• W2034987206 cites W2002367184 @default.
• W2034987206 cites W2005258142 @default.
• W2034987206 cites W2010063152 @default.
• W2034987206 cites W2016402142 @default.
• W2034987206 cites W2028116893 @default.
• W2034987206 cites W2034278799 @default.
• W2034987206 cites W2037613557 @default.
• W2034987206 cites W2039750140 @default.
• W2034987206 cites W2044037732 @default.
• W2034987206 cites W2049004196 @default.
• W2034987206 cites W2052321819 @default.
• W2034987206 cites W2054348180 @default.
• W2034987206 cites W2061597777 @default.
• W2034987206 cites W2062809197 @default.
• W2034987206 cites W2062839955 @default.
• W2034987206 cites W2073882664 @default.
• W2034987206 cites W2077378488 @default.
• W2034987206 cites W2077948032 @default.
• W2034987206 cites W2078605236 @default.
• W2034987206 cites W2080892549 @default.
• W2034987206 cites W2086487115 @default.
• W2034987206 cites W2091215253 @default.
• W2034987206 cites W2094437109 @default.
• W2034987206 cites W2122831371 @default.
• W2034987206 cites W2159183150 @default.
• W2034987206 cites W2952107737 @default.
• W2034987206 cites W4230229413 @default.
• W2034987206 cites W4235911281 @default.
• W2034987206 doi "https://doi.org/10.1016/0022-4731(88)90002-7" @default.
• W2034987206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3059053" @default.
• W2034987206 hasPublicationYear "1988" @default.
• W2034987206 type Work @default.
• W2034987206 sameAs 2034987206 @default.
• W2034987206 citedByCount "34" @default.
• W2034987206 countsByYear W20349872062012 @default.
• W2034987206 countsByYear W20349872062013 @default.
• W2034987206 countsByYear W20349872062021 @default.
• W2034987206 crossrefType "journal-article" @default.
• W2034987206 hasAuthorship W2034987206A5024296656 @default.
• W2034987206 hasAuthorship W2034987206A5038075414 @default.
• W2034987206 hasAuthorship W2034987206A5050519239 @default.
• W2034987206 hasAuthorship W2034987206A5054613179 @default.
• W2034987206 hasConcept C107824862 @default.
• W2034987206 hasConcept C121608353 @default.
• W2034987206 hasConcept C126322002 @default.
• W2034987206 hasConcept C134018914 @default.
• W2034987206 hasConcept C170493617 @default.
• W2034987206 hasConcept C185592680 @default.
• W2034987206 hasConcept C189135053 @default.
• W2034987206 hasConcept C2776069600 @default.
• W2034987206 hasConcept C2778938600 @default.
• W2034987206 hasConcept C2780902042 @default.
• W2034987206 hasConcept C530470458 @default.
• W2034987206 hasConcept C55493867 @default.
• W2034987206 hasConcept C59493245 @default.
• W2034987206 hasConcept C71240020 @default.
• W2034987206 hasConcept C71315377 @default.
• W2034987206 hasConcept C71924100 @default.
• W2034987206 hasConcept C84606932 @default.
• W2034987206 hasConcept C86803240 @default.
• W2034987206 hasConceptScore W2034987206C107824862 @default.
• W2034987206 hasConceptScore W2034987206C121608353 @default.
• W2034987206 hasConceptScore W2034987206C126322002 @default.
• W2034987206 hasConceptScore W2034987206C134018914 @default.
• W2034987206 hasConceptScore W2034987206C170493617 @default.
• W2034987206 hasConceptScore W2034987206C185592680 @default.
• W2034987206 hasConceptScore W2034987206C189135053 @default.
• W2034987206 hasConceptScore W2034987206C2776069600 @default.
• W2034987206 hasConceptScore W2034987206C2778938600 @default.
• W2034987206 hasConceptScore W2034987206C2780902042 @default.
• W2034987206 hasConceptScore W2034987206C530470458 @default.
• W2034987206 hasConceptScore W2034987206C55493867 @default.
• W2034987206 hasConceptScore W2034987206C59493245 @default.
• W2034987206 hasConceptScore W2034987206C71240020 @default.
• W2034987206 hasConceptScore W2034987206C71315377 @default.
• W2034987206 hasConceptScore W2034987206C71924100 @default.

• next