FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034987858> ?p ?o ?g. }

• W2034987858 abstract "Estrogens, environmental chemicals with carcinogenic potential, as well as oxidative and carbonyl stresses play a very important role in breast cancer (BC) genesis and progression. Therefore, polymorphisms of genes encoding enzymes involved in estrogen biosynthesis pathway and in the metabolic activation of pro-carcinogens to genotoxic intermediates, such as cytochrome P450C17α (CYP17), endogenous free-radical scavenging systems, such as glutathione S-transferase (GSTP1) and paraoxonase 1 (PON1), and anti-glycation defenses, such as glyoxalase I (GLO1), could influence individual susceptibility to BC. In the present case-control study, we investigated the possible association of CYP17 A1A2, GSTP1 ILE105VAL, PON1 Q192R or L55M, and GLO1 A111E polymorphisms with the risk of BC. The above-said five polymorphisms were characterized in 547 patients with BC and in 544 healthy controls by PCR/RFLP methods, using DNA from whole blood. To estimate the relative risks, Odds ratios and 95% confidence intervals were calculated using unconditional logistic regression after adjusting for the known risk factors for BC. CYP17 polymorphism had no major effect in BC proneness in the overall population. However, it modified the risk of BC for certain subgroups of patients. In particular, among premenopausal women with the A1A1 genotype, a protective effect of later age at menarche and parity was observed. As to GSTP1 and PON1 192 polymorphisms, the mutant Val and R alleles, respectively, were associated with a decreased risk of developing BC, while polymorphisms in PON1 55 and GLO1 were associated with an increased risk of this neoplasia. However, these findings, while nominally significant, did not withstand correction for multiple testing. Genetic polymorphisms in biotransformation enzymes CYP17, GSTP1, PON1 and GLO1 could be associated with the risk for BC. Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on the above mentioned genes and BC." @default.
• W2034987858 created "2016-06-24" @default.
• W2034987858 creator A5003644629 @default.
• W2034987858 creator A5008403882 @default.
• W2034987858 creator A5012991768 @default.
• W2034987858 creator A5019730319 @default.
• W2034987858 creator A5022206145 @default.
• W2034987858 creator A5051344370 @default.
• W2034987858 creator A5056578691 @default.
• W2034987858 creator A5078588212 @default.
• W2034987858 date "2009-04-20" @default.
• W2034987858 modified "2023-10-16" @default.
• W2034987858 title "CYP17, GSTP1, PON1 and GLO1gene polymorphisms as risk factors for breast cancer: an Italian case-control study" @default.
• W2034987858 cites W1671050155 @default.
• W2034987858 cites W1741537817 @default.
• W2034987858 cites W1876084901 @default.
• W2034987858 cites W1973275034 @default.
• W2034987858 cites W1976077212 @default.
• W2034987858 cites W1981841418 @default.
• W2034987858 cites W1983869761 @default.
• W2034987858 cites W1995584424 @default.
• W2034987858 cites W2000665880 @default.
• W2034987858 cites W2014174049 @default.
• W2034987858 cites W2015635131 @default.
• W2034987858 cites W2016710625 @default.
• W2034987858 cites W2019527863 @default.
• W2034987858 cites W2026550655 @default.
• W2034987858 cites W2037546651 @default.
• W2034987858 cites W2039356433 @default.
• W2034987858 cites W2039484557 @default.
• W2034987858 cites W2041017432 @default.
• W2034987858 cites W2043371968 @default.
• W2034987858 cites W2043744334 @default.
• W2034987858 cites W2046750894 @default.
• W2034987858 cites W2056647439 @default.
• W2034987858 cites W2056964101 @default.
• W2034987858 cites W2085342361 @default.
• W2034987858 cites W2108791332 @default.
• W2034987858 cites W2120305962 @default.
• W2034987858 cites W2125578916 @default.
• W2034987858 cites W2127854018 @default.
• W2034987858 cites W2131548572 @default.
• W2034987858 cites W2132434084 @default.
• W2034987858 cites W2139614919 @default.
• W2034987858 cites W2150980376 @default.
• W2034987858 cites W2151032397 @default.
• W2034987858 cites W2159950960 @default.
• W2034987858 cites W2163339050 @default.
• W2034987858 cites W2181909974 @default.
• W2034987858 cites W2309997197 @default.
• W2034987858 cites W3025790143 @default.
• W2034987858 doi "https://doi.org/10.1186/1471-2407-9-115" @default.
• W2034987858 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2680904" @default.
• W2034987858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19379515" @default.
• W2034987858 hasPublicationYear "2009" @default.
• W2034987858 type Work @default.
• W2034987858 sameAs 2034987858 @default.
• W2034987858 citedByCount "75" @default.
• W2034987858 countsByYear W20349878582012 @default.
• W2034987858 countsByYear W20349878582013 @default.
• W2034987858 countsByYear W20349878582014 @default.
• W2034987858 countsByYear W20349878582015 @default.
• W2034987858 countsByYear W20349878582016 @default.
• W2034987858 countsByYear W20349878582017 @default.
• W2034987858 countsByYear W20349878582018 @default.
• W2034987858 countsByYear W20349878582019 @default.
• W2034987858 countsByYear W20349878582020 @default.
• W2034987858 countsByYear W20349878582021 @default.
• W2034987858 countsByYear W20349878582022 @default.
• W2034987858 crossrefType "journal-article" @default.
• W2034987858 hasAuthorship W2034987858A5003644629 @default.
• W2034987858 hasAuthorship W2034987858A5008403882 @default.
• W2034987858 hasAuthorship W2034987858A5012991768 @default.
• W2034987858 hasAuthorship W2034987858A5019730319 @default.
• W2034987858 hasAuthorship W2034987858A5022206145 @default.
• W2034987858 hasAuthorship W2034987858A5051344370 @default.
• W2034987858 hasAuthorship W2034987858A5056578691 @default.
• W2034987858 hasAuthorship W2034987858A5078588212 @default.
• W2034987858 hasBestOaLocation W20349878581 @default.
• W2034987858 hasConcept C104317684 @default.
• W2034987858 hasConcept C114246631 @default.
• W2034987858 hasConcept C121608353 @default.
• W2034987858 hasConcept C126322002 @default.
• W2034987858 hasConcept C134018914 @default.
• W2034987858 hasConcept C135763542 @default.
• W2034987858 hasConcept C143998085 @default.
• W2034987858 hasConcept C146304588 @default.
• W2034987858 hasConcept C156957248 @default.
• W2034987858 hasConcept C2776151105 @default.
• W2034987858 hasConcept C2776509667 @default.
• W2034987858 hasConcept C2776601875 @default.
• W2034987858 hasConcept C2780122483 @default.
• W2034987858 hasConcept C37501387 @default.
• W2034987858 hasConcept C44249647 @default.
• W2034987858 hasConcept C530470458 @default.
• W2034987858 hasConcept C54355233 @default.
• W2034987858 hasConcept C71924100 @default.
• W2034987858 hasConcept C86803240 @default.
• W2034987858 hasConceptScore W2034987858C104317684 @default.
• W2034987858 hasConceptScore W2034987858C114246631 @default.

• next