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- W2034989390 abstract "Adamantanopyrrolidines 8, 9 and 10, adamantanopyrrolidines 16 and 18, adamantanoxazolone 20, adamantanopyrazolone 23, adamantanopyrazolothione 24 and adamantanocyclopentanamine 32 were synthesized and tested for anti-influenza A virus and trypanocidal activity. The stereoelectronic requirements for optimal antiviral and trypanocidal potency were investigated. Pyrrolidine 16 proved to be the most active of the compounds tested against influenza A virus, being 4-fold more active than amantadine, equipotent to rimantadine and 19-fold more potent than ribavirin. Oxazolone 20 showed significant trypanocidal activity against bloodstream forms of the African trypanosome, Trypanosoma brucei, being approximately 3 times more potent than rimantadine and almost 50-fold more active than amantadine." @default.
- W2034989390 created "2016-06-24" @default.
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- W2034989390 date "2008-01-01" @default.
- W2034989390 modified "2023-09-24" @default.
- W2034989390 title "Design and synthesis of bioactive 1,2-annulated adamantane derivatives" @default.
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- W2034989390 doi "https://doi.org/10.1039/b804907f" @default.
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