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- W2034989784 abstract "Scroll waves revolving at high frequency in the heart are responsible for fatal arrhythmias. Some mechanisms of arrhythmias require scroll waves to revolve at high frequency around an excitable filament. Recent ventricular cell models including calcium dynamics cannot reproduce this phenomenon. We address this problem revising sodium current kinetics and key phase II inward currents. We perform a nonlinear analysis of the sodium current gathered in canine cardiac myocytes. Despite an extensive data set, our nonlinear analysis shows that several Hodgkin-Huxley formalisms, i.e., a model family, reproduce the voltage clamp data. We incorporate formalisms taken from this family in the latest version of the Luo and Rudy cell model (LRd) and explore the parameter space for scroll wave dynamics. The simulations are performed on a monolayer of cells (3cm x 3cm) and portions (about 2/3) of the left ventricular free wall with realistic representation of the microanatomy. The Bidomain equations are solved at a resolution of 100um in space and 100us in time and are carried out on a supercomputer of the Texas Advanced Computer Center. Our bifurcation analysis shows that sodium current formalisms associated with higher threshold and slightly slower rate of rise during early depolarization may be more realistic. When combined with relatively minor revision of phase II plateau inward currents, the LRd model can produce scroll waves revolving around an excitable filament. The revised model exhibits a rotation period significantly briefer than the original one, and even briefer than the refractory period measured on a plane wave. This mode of excitation allows us to study mechanisms of cardiac death. In conclusion, revision of sodium current kinetics and phase II inward currents of the LRd model allows to realistically reproduce scroll wave revolving around unexcited filament." @default.
- W2034989784 created "2016-06-24" @default.
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- W2034989784 date "2012-01-01" @default.
- W2034989784 modified "2023-10-18" @default.
- W2034989784 title "Ionic Mechanism for the Formation of Excitable Scroll Wave Filaments" @default.
- W2034989784 doi "https://doi.org/10.1016/j.bpj.2011.11.2962" @default.
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