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• W2034991968 abstract "To investigate the effects of transdermal 17 beta-estradiol (E(2)) compared with oral unopposed as well as opposed E(2) on echocardiographic parameters of left ventricular (LV) systolic and diastolic function.A prospective, randomized, double-blind, placebo-controlled, multi-center study.Gynecologic and cardiologic outpatient departments.One hundred fifty-two healthy hysterectomized postmenopausal women.Participants received daily placebo (n = 49) or transdermal E(2) (50 microg; tE(2) group, n = 33), or oral E(2) (1 mg; oE(2) group, n = 37), or oral E(2) (1 mg) combined with gestodene (25 microg; oE(2)+G group, n = 33) for thirteen 28-day treatment cycles.M-mode, quantitative two-dimensional, and Doppler echocardiographic measurements were performed at baseline and after 1 year.Compared with placebo, tE(2) and oE(2) showed no statistically significant changes in LV function. oE(2)+G resulted in a statistically significant favorable increase in peak flow velocity, flow velocity integral, and mean acceleration. Furthermore, a favorable decrease was observed in interventricular septum thickness and ejection time.After 1 year of unopposed E(2), LV function remained unchanged. The oE(2)+G treatment showed a potential beneficial influence on LV systolic function." @default.
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• W2034991968 date "2003-09-01" @default.
• W2034991968 modified "2023-10-13" @default.
• W2034991968 title "Effects of oral and transdermal low-dose estrogen therapy on echocardiographic parameters of cardiac function" @default.
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• W2034991968 doi "https://doi.org/10.1016/s0015-0282(03)00754-4" @default.
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