FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034992143> ?p ?o ?g. }

• W2034992143 endingPage "169" @default.
• W2034992143 startingPage "164" @default.
• W2034992143 abstract "Individual variability of the pharmacokinetics of prednisolone based on the unbound concentration in plasma is of significant clinical consideration. The unbound concentrations of prednisolone were measured in 10 patients with nephrotic syndrome, two patients with systemic lupus erythematosus, and one patient with dermatomyositis by examining protein bindings of prednisolone on one or more occasions during prednisolone treatment. In this study, plasma concentrations of prednisolone, prednisone, cortisol, and cortisone were simultaneously analyzed by GC–MS by using stable isotope-labeled internal standards. Equilibrium dialysis was employed to accurately estimate the unbound fractions of prednisolone in plasma. The unbound fraction of prednisolone changed depending on plasma total prednisolone concentration and plasma albumin concentration. The unbound fraction of prednisolone (Y) is calculated: Y = (−0.0101x′ + 0.0736) x + 10.23, where x′ is the plasma albumin concentration and x is the total prednisolone concentration. The estimated concentrations of unbound prednisolone by using the above equation were in good agreement with the measured concentrations of unbound prednisolone. Since the protein binding of prednisolone did not change in the presence of prednisone (114.0 ng/ml), it appeared that prednisone produced from the therapeutic dose of prednisolone did not affect the unbound fraction of prednisolone." @default.
• W2034992143 created "2016-06-24" @default.
• W2034992143 creator A5000772399 @default.
• W2034992143 creator A5001665811 @default.
• W2034992143 creator A5013653271 @default.
• W2034992143 creator A5016639735 @default.
• W2034992143 creator A5033302261 @default.
• W2034992143 creator A5050395893 @default.
• W2034992143 creator A5081414172 @default.
• W2034992143 creator A5088207236 @default.
• W2034992143 date "2008-07-01" @default.
• W2034992143 modified "2023-09-28" @default.
• W2034992143 title "Simultaneous determination of prednisolone, prednisone, cortisol, and cortisone in plasma by GC–MS: Estimating unbound prednisolone concentration in patients with nephrotic syndrome during oral prednisolone therapy" @default.
• W2034992143 cites W1538795472 @default.
• W2034992143 cites W1917375005 @default.
• W2034992143 cites W1963490606 @default.
• W2034992143 cites W1973215624 @default.
• W2034992143 cites W1978792181 @default.
• W2034992143 cites W1987319226 @default.
• W2034992143 cites W1988300467 @default.
• W2034992143 cites W1988342842 @default.
• W2034992143 cites W1989107666 @default.
• W2034992143 cites W1995612143 @default.
• W2034992143 cites W1999417904 @default.
• W2034992143 cites W2006667131 @default.
• W2034992143 cites W2010500561 @default.
• W2034992143 cites W2015629888 @default.
• W2034992143 cites W2019733623 @default.
• W2034992143 cites W2032149805 @default.
• W2034992143 cites W2034100631 @default.
• W2034992143 cites W2035346449 @default.
• W2034992143 cites W2037876998 @default.
• W2034992143 cites W2040255685 @default.
• W2034992143 cites W2051084741 @default.
• W2034992143 cites W2051419032 @default.
• W2034992143 cites W2063000682 @default.
• W2034992143 cites W2067839819 @default.
• W2034992143 cites W2072912951 @default.
• W2034992143 cites W2092362939 @default.
• W2034992143 cites W2165775938 @default.
• W2034992143 cites W2319305616 @default.
• W2034992143 doi "https://doi.org/10.1016/j.jchromb.2008.03.003" @default.
• W2034992143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18387858" @default.
• W2034992143 hasPublicationYear "2008" @default.
• W2034992143 type Work @default.
• W2034992143 sameAs 2034992143 @default.
• W2034992143 citedByCount "35" @default.
• W2034992143 countsByYear W20349921432012 @default.
• W2034992143 countsByYear W20349921432013 @default.
• W2034992143 countsByYear W20349921432014 @default.
• W2034992143 countsByYear W20349921432015 @default.
• W2034992143 countsByYear W20349921432016 @default.
• W2034992143 countsByYear W20349921432017 @default.
• W2034992143 countsByYear W20349921432018 @default.
• W2034992143 countsByYear W20349921432019 @default.
• W2034992143 countsByYear W20349921432020 @default.
• W2034992143 countsByYear W20349921432021 @default.
• W2034992143 countsByYear W20349921432022 @default.
• W2034992143 countsByYear W20349921432023 @default.
• W2034992143 crossrefType "journal-article" @default.
• W2034992143 hasAuthorship W2034992143A5000772399 @default.
• W2034992143 hasAuthorship W2034992143A5001665811 @default.
• W2034992143 hasAuthorship W2034992143A5013653271 @default.
• W2034992143 hasAuthorship W2034992143A5016639735 @default.
• W2034992143 hasAuthorship W2034992143A5033302261 @default.
• W2034992143 hasAuthorship W2034992143A5050395893 @default.
• W2034992143 hasAuthorship W2034992143A5081414172 @default.
• W2034992143 hasAuthorship W2034992143A5088207236 @default.
• W2034992143 hasConcept C126322002 @default.
• W2034992143 hasConcept C134018914 @default.
• W2034992143 hasConcept C185592680 @default.
• W2034992143 hasConcept C2776125364 @default.
• W2034992143 hasConcept C2776715498 @default.
• W2034992143 hasConcept C2778720950 @default.
• W2034992143 hasConcept C2780484280 @default.
• W2034992143 hasConcept C43617362 @default.
• W2034992143 hasConcept C55493867 @default.
• W2034992143 hasConcept C71924100 @default.
• W2034992143 hasConceptScore W2034992143C126322002 @default.
• W2034992143 hasConceptScore W2034992143C134018914 @default.
• W2034992143 hasConceptScore W2034992143C185592680 @default.
• W2034992143 hasConceptScore W2034992143C2776125364 @default.
• W2034992143 hasConceptScore W2034992143C2776715498 @default.
• W2034992143 hasConceptScore W2034992143C2778720950 @default.
• W2034992143 hasConceptScore W2034992143C2780484280 @default.
• W2034992143 hasConceptScore W2034992143C43617362 @default.
• W2034992143 hasConceptScore W2034992143C55493867 @default.
• W2034992143 hasConceptScore W2034992143C71924100 @default.
• W2034992143 hasIssue "2" @default.
• W2034992143 hasLocation W20349921431 @default.
• W2034992143 hasLocation W20349921432 @default.
• W2034992143 hasOpenAccess W2034992143 @default.
• W2034992143 hasPrimaryLocation W20349921431 @default.
• W2034992143 hasRelatedWork W1981953352 @default.
• W2034992143 hasRelatedWork W1987354827 @default.
• W2034992143 hasRelatedWork W2053073845 @default.
• W2034992143 hasRelatedWork W2062839436 @default.
• W2034992143 hasRelatedWork W2086273974 @default.

• next