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- W2034994712 abstract "In this study, we report a novel anticarcinogenic activity of an organosulfur compound from garlic, diallyl disulfide (DADS). DADS treatment significantly inhibited the growth of H-rasoncogene transformed tumors in nude mice. As compared to controls, the appearance of tumors was also delayed markedly by oral administration of DADS. The inhibition of tumor growth by DADS treatment correlated with the inhibition of p21H-rasmembrane association in the tumor tissue. The levels of membrane associated p21H-raswere markedly lower in the tumor tissues of DADS treated mice as compared to controls. An opposite trend, however, was evident for cytosolic p21H-ras. Furthermore, DADS treatment resulted in a significant inhibition of hepatic as well as tumoral 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. These results indicate that DADS suppresses the growth of H-rasoncogene transformed tumors in nude mice by inhibiting the membrane association of tumoral p21H-ras." @default.
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- W2034994712 title "Novel Anti-Carcinogenic Activity of an Organosulfide from Garlic: Inhibition of H-RASOncogene Transformed Tumor Growthin Vivoby Diallyl Disulfide Is Associated with Inhibition of p21H-rasProcessing" @default.
- W2034994712 doi "https://doi.org/10.1006/bbrc.1996.1226" @default.
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