Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034994780> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2034994780 abstract "Retinoids and steroid hormones mediate their biological effects through nuclear receptors. However, retinoids may alter the intracellular availability of ligands for steroid receptor activation by modulating the activity of biotransformation enzymes. This study investigated the modulation of NAD(H)-linked steroid oxidoreductases in rat hepatic microsomes by retinoids. 13-cis-Retinoic acid inhibited testosterone 17 beta-dehydrogenation (Ki 2.4 +/- 0.5 microM; Km/Ki ratio 0.34 +/- 0.06) but androstenedione reduction was less susceptible to inhibition (Ki 27 +/- 13 microM; Km/Ki ratio 0.045 +/- 0.12). All-trans-retinoic acid was less potent than the 13-cis-isomer and 9-cis-retinoic acid was of intermediate potency. In vivo administration of all-trans-retinoic acid (60 mg/kg i.p. for 7 days) decreased hepatic microsomal oxidoreduction activity, but exposure over shorter periods and 13-cis-retinoic acid were without effect. Thus, all-trans-retinoic acid elicits direct inhibition and may also alter the normal regulation of the oxidoreductase under certain conditions. Three geometric isomers of retinal were potent inhibitors of testosterone dehydrogenation (IC50s approximately 6 microM), but were ineffective against androstenedione reduction. These findings suggest that certain anti-hormonal effects of retinoids may be attributable in part to modulation of endobiotic biotransformation prior to receptor binding and activation." @default.
- W2034994780 created "2016-06-24" @default.
- W2034994780 creator A5003967548 @default.
- W2034994780 creator A5059734230 @default.
- W2034994780 creator A5089184763 @default.
- W2034994780 date "1994-06-01" @default.
- W2034994780 modified "2023-10-16" @default.
- W2034994780 title "Inhibition of microsomal 17β-hydroxysteroid oxidoreduction activities in rat liver by all-trans-, 9-cis- and 13-cis-retinoic acid" @default.
- W2034994780 cites W1554236013 @default.
- W2034994780 cites W1570165358 @default.
- W2034994780 cites W1633747844 @default.
- W2034994780 cites W1775749144 @default.
- W2034994780 cites W1966790550 @default.
- W2034994780 cites W1967858466 @default.
- W2034994780 cites W1969589455 @default.
- W2034994780 cites W1987321551 @default.
- W2034994780 cites W2032711347 @default.
- W2034994780 cites W2032895297 @default.
- W2034994780 cites W2046782580 @default.
- W2034994780 cites W2053131171 @default.
- W2034994780 cites W2065693137 @default.
- W2034994780 cites W2078327697 @default.
- W2034994780 cites W2082262367 @default.
- W2034994780 cites W2086550152 @default.
- W2034994780 cites W2093802942 @default.
- W2034994780 cites W2254919660 @default.
- W2034994780 cites W94260358 @default.
- W2034994780 doi "https://doi.org/10.1016/0167-4889(94)90173-2" @default.
- W2034994780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8031859" @default.
- W2034994780 hasPublicationYear "1994" @default.
- W2034994780 type Work @default.
- W2034994780 sameAs 2034994780 @default.
- W2034994780 citedByCount "7" @default.
- W2034994780 countsByYear W20349947802012 @default.
- W2034994780 crossrefType "journal-article" @default.
- W2034994780 hasAuthorship W2034994780A5003967548 @default.
- W2034994780 hasAuthorship W2034994780A5059734230 @default.
- W2034994780 hasAuthorship W2034994780A5089184763 @default.
- W2034994780 hasConcept C104317684 @default.
- W2034994780 hasConcept C120197328 @default.
- W2034994780 hasConcept C126322002 @default.
- W2034994780 hasConcept C134018914 @default.
- W2034994780 hasConcept C150903083 @default.
- W2034994780 hasConcept C170493617 @default.
- W2034994780 hasConcept C181199279 @default.
- W2034994780 hasConcept C185592680 @default.
- W2034994780 hasConcept C207001950 @default.
- W2034994780 hasConcept C2779963572 @default.
- W2034994780 hasConcept C2780902042 @default.
- W2034994780 hasConcept C2781121885 @default.
- W2034994780 hasConcept C55493867 @default.
- W2034994780 hasConcept C71315377 @default.
- W2034994780 hasConcept C71924100 @default.
- W2034994780 hasConcept C86803240 @default.
- W2034994780 hasConcept C87644729 @default.
- W2034994780 hasConceptScore W2034994780C104317684 @default.
- W2034994780 hasConceptScore W2034994780C120197328 @default.
- W2034994780 hasConceptScore W2034994780C126322002 @default.
- W2034994780 hasConceptScore W2034994780C134018914 @default.
- W2034994780 hasConceptScore W2034994780C150903083 @default.
- W2034994780 hasConceptScore W2034994780C170493617 @default.
- W2034994780 hasConceptScore W2034994780C181199279 @default.
- W2034994780 hasConceptScore W2034994780C185592680 @default.
- W2034994780 hasConceptScore W2034994780C207001950 @default.
- W2034994780 hasConceptScore W2034994780C2779963572 @default.
- W2034994780 hasConceptScore W2034994780C2780902042 @default.
- W2034994780 hasConceptScore W2034994780C2781121885 @default.
- W2034994780 hasConceptScore W2034994780C55493867 @default.
- W2034994780 hasConceptScore W2034994780C71315377 @default.
- W2034994780 hasConceptScore W2034994780C71924100 @default.
- W2034994780 hasConceptScore W2034994780C86803240 @default.
- W2034994780 hasConceptScore W2034994780C87644729 @default.
- W2034994780 hasLocation W20349947801 @default.
- W2034994780 hasLocation W20349947802 @default.
- W2034994780 hasOpenAccess W2034994780 @default.
- W2034994780 hasPrimaryLocation W20349947801 @default.
- W2034994780 hasRelatedWork W2004141120 @default.
- W2034994780 hasRelatedWork W2010372900 @default.
- W2034994780 hasRelatedWork W2034994780 @default.
- W2034994780 hasRelatedWork W2074076166 @default.
- W2034994780 hasRelatedWork W2074363506 @default.
- W2034994780 hasRelatedWork W2083727024 @default.
- W2034994780 hasRelatedWork W2094419359 @default.
- W2034994780 hasRelatedWork W2409420542 @default.
- W2034994780 hasRelatedWork W2413189091 @default.
- W2034994780 hasRelatedWork W2950894116 @default.
- W2034994780 isParatext "false" @default.
- W2034994780 isRetracted "false" @default.
- W2034994780 magId "2034994780" @default.
- W2034994780 workType "article" @default.