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• W2034999130 abstract "Nematode infections are generally followed by high rates of reinfection, leading to elevated prevalence in endemic areas. Therefore, the effective control of nematode infections depends on understanding the induction and regulation of protective mechanisms. However, most experimental models for protective immune response against nematodes use high parasite exposure, not always reflecting what occurs naturally in human populations. In this study, we tested whether infecting mice with different Strongyloides venezuelensis larvae loads would affect protective responses against reinfection. Interestingly, we found that a previous infection with 10-500 larvae conferred high rate of protection against reinfection with S. venezuelensis in mice, by destroying large numbers of migrating larvae. However, low-dose priming did not abolish adult worm maturation, as detected in high-dose primed group. Results also indicated that a previous low-dose infection delayed the development of cellular infiltrate, while a high inoculum rapidly induced these inflammatory features. Cytokine production by splenocyte cultures of challenge infected mice demonstrated that low-dose priming had increased production of IL-4 and IFN-gamma, while high-dose induced IL-4 production but not IFN-gamma. Our data support the hypothesis that low-dose nematode infection does not induce a polarized type-2 immune response, allowing adult worm survival." @default.
• W2034999130 created "2016-06-24" @default.
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• W2034999130 date "2010-03-01" @default.
• W2034999130 modified "2023-10-06" @default.
• W2034999130 title "Regulation of immune responses to<i>Strongyloides venezuelensis</i>challenge after primary infection with different larvae doses" @default.
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• W2034999130 doi "https://doi.org/10.1111/j.1365-3024.2009.01176.x" @default.
• W2034999130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20398181" @default.
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