FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035000161> ?p ?o ?g. }

• W2035000161 abstract "We previously reported that angiotensin-II (AII) stimulated and dopamine (DA) inhibited the release of human placental lactogen (hPL) from trophoblastic cells. The mechanisms of action involved in these endocrine regulations are poorly known. In this study, we investigated the role of Ca2+ as a potential cellular mediator of the effects of AII and DA. Incubation of freshly isolated human term trophoblastic cells with DA led to a dose-dependent inhibition of 45Ca2+ influx, with a maximum of 55 +/- 5% and an EC50 of 10 +/- 3 mumol/L. This DA-inhibited Ca2+ influx was reversed by spiperone, a D2-dopamine receptor antagonist. Preincubation of cells with pertussis toxin completely blocked the inhibitory effect of DA on placental 45Ca2+ influx. Nifedipine (10(-5) mol/L), like DA, inhibited 45Ca2+ influx (41 +/- 3% inhibition). Moreover, nifedipine decreased hPL release (57 +/- 10%; EC50, 0.25 +/- 0.09 mumol/L). Coincubation of DA and nifedipine did not enhance the inhibitory effects of these agents on either 45Ca2+ influx or hPL release. The incubation of trophoblastic cells with [Sar1]AII, a potent agonist of AII, led to a dose-dependent stimulation of 45Ca2+ influx. The maximal stimulation was 221 +/- 37% of the control value, with an EC50 of 50 +/- 15 nmol/L. This stimulation was inhibited by coincubation with the AII antagonist [Sar1,Ala8]AII. [Sar1]AII-stimulated Ca2+ influx was blocked by preincubation with pertussis toxin. Bay K 8644 also stimulated 45Ca2+ influx (238 +/- 41% of the control). Moreover, Bay K 8644 stimulated hPL release. The maximal stimulation was 180 +/- 22% of the control value, with an EC50 of 0.40 +/- 0.30 mumol/L. Coincubation of Bay K 8644 and AII did not led to additional stimulation of either 45Ca2+ influx or hPL release. These results suggest that Ca2+ influx is one mechanism that mediates AII and DA regulation of hPL release in human term trophoblastic cells." @default.
• W2035000161 created "2016-06-24" @default.
• W2035000161 creator A5011162166 @default.
• W2035000161 creator A5012572436 @default.
• W2035000161 creator A5023885518 @default.
• W2035000161 creator A5025932075 @default.
• W2035000161 creator A5032143796 @default.
• W2035000161 creator A5091477954 @default.
• W2035000161 date "1993-09-01" @default.
• W2035000161 modified "2023-10-02" @default.
• W2035000161 title "A role for extracellular calcium in the regulation of placental lactogen release by angiotensin-II and dopamine in human term trophoblastic cells." @default.
• W2035000161 cites W1520305904 @default.
• W2035000161 cites W1663592530 @default.
• W2035000161 cites W177974401 @default.
• W2035000161 cites W1877788794 @default.
• W2035000161 cites W1901681320 @default.
• W2035000161 cites W1978739653 @default.
• W2035000161 cites W1989664221 @default.
• W2035000161 cites W1992574623 @default.
• W2035000161 cites W1999495248 @default.
• W2035000161 cites W1999711732 @default.
• W2035000161 cites W2001290018 @default.
• W2035000161 cites W2005385083 @default.
• W2035000161 cites W2013166832 @default.
• W2035000161 cites W2016916600 @default.
• W2035000161 cites W2025456853 @default.
• W2035000161 cites W2028663947 @default.
• W2035000161 cites W2032036679 @default.
• W2035000161 cites W2035789402 @default.
• W2035000161 cites W2036125503 @default.
• W2035000161 cites W2040160154 @default.
• W2035000161 cites W2054639283 @default.
• W2035000161 cites W2069635660 @default.
• W2035000161 cites W2078840743 @default.
• W2035000161 cites W2093619119 @default.
• W2035000161 cites W2117479689 @default.
• W2035000161 cites W2130667022 @default.
• W2035000161 cites W2165422440 @default.
• W2035000161 cites W2187930412 @default.
• W2035000161 cites W2260930859 @default.
• W2035000161 cites W2429406161 @default.
• W2035000161 cites W2432344110 @default.
• W2035000161 cites W92460469 @default.
• W2035000161 doi "https://doi.org/10.1210/jcem.77.3.7690361" @default.
• W2035000161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7690361" @default.
• W2035000161 hasPublicationYear "1993" @default.
• W2035000161 type Work @default.
• W2035000161 sameAs 2035000161 @default.
• W2035000161 citedByCount "7" @default.
• W2035000161 countsByYear W20350001612012 @default.
• W2035000161 crossrefType "journal-article" @default.
• W2035000161 hasAuthorship W2035000161A5011162166 @default.
• W2035000161 hasAuthorship W2035000161A5012572436 @default.
• W2035000161 hasAuthorship W2035000161A5023885518 @default.
• W2035000161 hasAuthorship W2035000161A5025932075 @default.
• W2035000161 hasAuthorship W2035000161A5032143796 @default.
• W2035000161 hasAuthorship W2035000161A5091477954 @default.
• W2035000161 hasConcept C126322002 @default.
• W2035000161 hasConcept C134018914 @default.
• W2035000161 hasConcept C170493617 @default.
• W2035000161 hasConcept C185592680 @default.
• W2035000161 hasConcept C24998067 @default.
• W2035000161 hasConcept C2776823063 @default.
• W2035000161 hasConcept C2778938600 @default.
• W2035000161 hasConcept C2908929049 @default.
• W2035000161 hasConcept C49773422 @default.
• W2035000161 hasConcept C519063684 @default.
• W2035000161 hasConcept C71924100 @default.
• W2035000161 hasConcept C80631254 @default.
• W2035000161 hasConcept C86803240 @default.
• W2035000161 hasConceptScore W2035000161C126322002 @default.
• W2035000161 hasConceptScore W2035000161C134018914 @default.
• W2035000161 hasConceptScore W2035000161C170493617 @default.
• W2035000161 hasConceptScore W2035000161C185592680 @default.
• W2035000161 hasConceptScore W2035000161C24998067 @default.
• W2035000161 hasConceptScore W2035000161C2776823063 @default.
• W2035000161 hasConceptScore W2035000161C2778938600 @default.
• W2035000161 hasConceptScore W2035000161C2908929049 @default.
• W2035000161 hasConceptScore W2035000161C49773422 @default.
• W2035000161 hasConceptScore W2035000161C519063684 @default.
• W2035000161 hasConceptScore W2035000161C71924100 @default.
• W2035000161 hasConceptScore W2035000161C80631254 @default.
• W2035000161 hasConceptScore W2035000161C86803240 @default.
• W2035000161 hasLocation W20350001611 @default.
• W2035000161 hasLocation W20350001612 @default.
• W2035000161 hasOpenAccess W2035000161 @default.
• W2035000161 hasPrimaryLocation W20350001611 @default.
• W2035000161 hasRelatedWork W1966583389 @default.
• W2035000161 hasRelatedWork W1978940436 @default.
• W2035000161 hasRelatedWork W1989120855 @default.
• W2035000161 hasRelatedWork W1994154819 @default.
• W2035000161 hasRelatedWork W2029512301 @default.
• W2035000161 hasRelatedWork W2030498869 @default.
• W2035000161 hasRelatedWork W2031163417 @default.
• W2035000161 hasRelatedWork W2050836208 @default.
• W2035000161 hasRelatedWork W2115845384 @default.
• W2035000161 hasRelatedWork W1996764561 @default.
• W2035000161 isParatext "false" @default.
• W2035000161 isRetracted "false" @default.
• W2035000161 magId "2035000161" @default.

• next