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- W2035007761 abstract "Glutamine synthetase (GS) plays a key role in the regulation of glutamate availability to neurons. In the present study glutamine synthetase was immobilized on a silica-based immobilized artificial membrane liquid chromatographic stationary phase (IAM-SP) to create the GS-IAM. The stability of GS was improved by immobilization, but the enzyme's affinity for the substrates L-glutamate and D-glutamate was significantly decreased. In contrast, immobilization significantly increased GS sensitivity to inhibition by methionine sulfoximine. The GS-IAM was packed into a chromatography column to create an immobilized enzyme reactor (GS-IMER). On-line experiments with the GS-IMER demonstrated that the immobilized enzyme was comparable to the non-immobilized enzyme with regards to retention of activity and selectivity toward substrates and inhibitors and was reusable for several weeks." @default.
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- W2035007761 date "2001-04-01" @default.
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- W2035007761 title "Development of an immobilized brain glutamine synthetase liquid chromatographic stationary phase for on-line biochemical studies" @default.
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- W2035007761 doi "https://doi.org/10.1016/s0021-9673(01)00581-7" @default.
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