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• W2035009293 abstract "Actinomyces are among the predominant bacteria in the oral microflora. This review discusses the glucose and lactate metabolism of Actinomyces naeslundii and its ecological significance in dental plaque. This bacterium has the Embden-Meyerhof-Parnas (EMP) pathway as the main route to degrade glucose. The EMP pathway-derived metabolic intermediates, phosphoenolpyruvate (PEP) and pyruvate, are further converted into different end-products, depending on the environment. Under anaerobic conditions in the absence of bicarbonate, the pyruvate is converted into lactate by a lactate dehydrogenase. In the presence of bicarbonate, the PEP is combined with bicarbonate and then converted into succinate through the succinate pathway, while the pyruvate is converted into formate and acetate through the pyruvate formate-lyase pathway. Under aerobic conditions, the pyruvate liberates acetate and CO2 through a pathway initiated by a pyruvate dehydrogenase. A. naeslundii strains also degrade lactate, aerobically, to acetate and CO2 through the conversion of lactate into pyruvate by a NAD-independent lactate dehydrogenase. These strains also synthesize glycogen from a glycolytic intermediate, glucose 6-phosphate. Besides atmospheric conditions and bicarbonate, the intracellular reduction-oxidation potential, carbohydrate concentration, and environmental pH also modulate the metabolism of A. naeslundii. Some of the phosphorylating enzymes involved in A. naeslundii metabolism--e.g., GTP/polyphosphate (PPn)-dependent glucokinase, pyrophosphate (PPi)-dependent phosphofructokinase, UDP-glucose pyrophosphorylase, and GDP/IDP-dependent PEP carboxykinase--are unique to A. naeslundii and have not been found in other oral bacteria. The utilization of PPn and PPi as phosphoryl donors, together with glycogen synthesis and lactate utilization, could contribute to the efficient energy metabolism found in A. naeslundii. Through this flexible and efficient metabolic capacity, A. naeslundii can adapt to fluctuating environments and compete with other bacteria in dental plaque. Further, this bacterium may modify the dental plaque environment and promote the microbial population shifts in dental plaque." @default.
• W2035009293 created "2016-06-24" @default.
• W2035009293 creator A5010077070 @default.
• W2035009293 creator A5051273148 @default.
• W2035009293 date "1999-07-01" @default.
• W2035009293 modified "2023-10-18" @default.
• W2035009293 title "Glucose and Lactate Metabolism By Actinomyces Naeslundii" @default.
• W2035009293 cites W107597930 @default.
• W2035009293 cites W1507882192 @default.
• W2035009293 cites W1512544785 @default.
• W2035009293 cites W1513975730 @default.
• W2035009293 cites W1526998534 @default.
• W2035009293 cites W1541405218 @default.
• W2035009293 cites W1542883299 @default.
• W2035009293 cites W1570108887 @default.
• W2035009293 cites W1588496734 @default.
• W2035009293 cites W1590716205 @default.
• W2035009293 cites W1591613693 @default.
• W2035009293 cites W1596909056 @default.
• W2035009293 cites W1619024760 @default.
• W2035009293 cites W1815987069 @default.
• W2035009293 cites W1826097838 @default.
• W2035009293 cites W1857337524 @default.
• W2035009293 cites W1870514323 @default.
• W2035009293 cites W1872374211 @default.
• W2035009293 cites W1886537447 @default.
• W2035009293 cites W1899844715 @default.
• W2035009293 cites W1900623310 @default.
• W2035009293 cites W1927383242 @default.
• W2035009293 cites W1942645275 @default.
• W2035009293 cites W1948915420 @default.
• W2035009293 cites W1954018204 @default.
• W2035009293 cites W1965916241 @default.
• W2035009293 cites W1966086436 @default.
• W2035009293 cites W1971875650 @default.
• W2035009293 cites W1974414565 @default.
• W2035009293 cites W1978382470 @default.
• W2035009293 cites W1979618288 @default.
• W2035009293 cites W1982399957 @default.
• W2035009293 cites W1984123403 @default.
• W2035009293 cites W1985395810 @default.
• W2035009293 cites W1986073667 @default.
• W2035009293 cites W1987540881 @default.
• W2035009293 cites W1988031881 @default.
• W2035009293 cites W1989421659 @default.
• W2035009293 cites W1989560153 @default.
• W2035009293 cites W1990891311 @default.
• W2035009293 cites W1991102189 @default.
• W2035009293 cites W1994290217 @default.
• W2035009293 cites W1998670987 @default.
• W2035009293 cites W1999222803 @default.
• W2035009293 cites W2001010517 @default.
• W2035009293 cites W2004440727 @default.
• W2035009293 cites W2007983271 @default.
• W2035009293 cites W2011773568 @default.
• W2035009293 cites W2012349889 @default.
• W2035009293 cites W2013245576 @default.
• W2035009293 cites W2016771879 @default.
• W2035009293 cites W2035388280 @default.
• W2035009293 cites W2041406496 @default.
• W2035009293 cites W2041440438 @default.
• W2035009293 cites W2048296708 @default.
• W2035009293 cites W2049708122 @default.
• W2035009293 cites W2058023235 @default.
• W2035009293 cites W2059340938 @default.
• W2035009293 cites W2060208386 @default.
• W2035009293 cites W2062851608 @default.
• W2035009293 cites W2064575703 @default.
• W2035009293 cites W2070625036 @default.
• W2035009293 cites W2071451674 @default.
• W2035009293 cites W2072808152 @default.
• W2035009293 cites W2073027829 @default.
• W2035009293 cites W2075786060 @default.
• W2035009293 cites W2076218054 @default.
• W2035009293 cites W2082849942 @default.
• W2035009293 cites W2083467196 @default.
• W2035009293 cites W2090156042 @default.
• W2035009293 cites W2091680242 @default.
• W2035009293 cites W2099376584 @default.
• W2035009293 cites W2099723868 @default.
• W2035009293 cites W2100546872 @default.
• W2035009293 cites W2105068113 @default.
• W2035009293 cites W2113776769 @default.
• W2035009293 cites W2115609008 @default.
• W2035009293 cites W2126896014 @default.
• W2035009293 cites W2131808320 @default.
• W2035009293 cites W2132692846 @default.
• W2035009293 cites W2133508938 @default.
• W2035009293 cites W2134860701 @default.
• W2035009293 cites W2135144352 @default.
• W2035009293 cites W2139969141 @default.
• W2035009293 cites W2141474578 @default.
• W2035009293 cites W2145301793 @default.
• W2035009293 cites W2151855265 @default.
• W2035009293 cites W2152176461 @default.
• W2035009293 cites W2156649207 @default.
• W2035009293 cites W2157742168 @default.
• W2035009293 cites W2157826333 @default.

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