FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035009609> ?p ?o ?g. }

• W2035009609 endingPage "314" @default.
• W2035009609 startingPage "306" @default.
• W2035009609 abstract "Endothelin-1, angiotensin II, and oxygen-derived radicals are pivotal factors in the development and progression of atherosclerosis. In vitro studies suggest that generation of oxygen-derived radicals by angiotensin II is an important mechanism increasing endothelin-1 synthesis, which consecutively may trigger effects such as cell proliferation and hypertrophy. The aim of this study was to confirm our previous data in an ex vivo and an in vivo setting. Explanted segments of internal mammary arteries were analyzed for big endothelin-1 expression following incubation with xanthine oxidase, angiotensin II, superoxide dismutase, and catalase to stimulate or to specifically inactivate oxygen-derived radicals. Endothelin-1 concentrations were determined by immunostaining and enzyme-linked immunosorbent assay. Further, oxypurinol was given to patients undergoing coronary angioplasty, a procedure known to increase plasma endothelin-1 concentrations. Angiotensin II and xanthine oxidase dose-dependently increased big endothelin-1 concentrations (p < .01 and p < .0001); the effects could be inhibited by coincubation with superoxide dismutase and catalase as determined by both semiquantitative immunofluorescence and enzyme-linked immunosorbent assay (p < .01). Patients undergoing coronary angioplasty exhibited significantly elevated big endothelin-1 concentrations 60 minutes after angioplasty (p = .03); in patients also receiving oxypurinol immediately after angioplasty, big endothelin-1 concentrations decreased (p = .001). Our results may explain the association between elevated angiotensin II levels, increased oxidative stress, and increased endothelin-1 concentrations in atherosclerosis. The data therefore support the concept that oxygen-derived free radicals stimulate the release of endothelin-1, which subsequently induces effects such as proliferation and enhanced agonist-induced vasoconstriction, previously attributed directly to angiotensin II." @default.
• W2035009609 created "2016-06-24" @default.
• W2035009609 creator A5000900815 @default.
• W2035009609 creator A5003396372 @default.
• W2035009609 creator A5017439924 @default.
• W2035009609 creator A5031080698 @default.
• W2035009609 creator A5035254382 @default.
• W2035009609 creator A5053048440 @default.
• W2035009609 creator A5062212384 @default.
• W2035009609 creator A5075655406 @default.
• W2035009609 date "2007-09-01" @default.
• W2035009609 modified "2023-09-27" @default.
• W2035009609 title "Endothelin-1 in Humans is Increased by Oxygen-Derived Radicals Ex Vivo and in Vivo" @default.
• W2035009609 cites W1976555160 @default.
• W2035009609 cites W1978603134 @default.
• W2035009609 cites W1989679961 @default.
• W2035009609 cites W1989924068 @default.
• W2035009609 cites W1992356517 @default.
• W2035009609 cites W2000208057 @default.
• W2035009609 cites W2005593895 @default.
• W2035009609 cites W2012018808 @default.
• W2035009609 cites W2012323656 @default.
• W2035009609 cites W2013336783 @default.
• W2035009609 cites W2033870657 @default.
• W2035009609 cites W2055877133 @default.
• W2035009609 cites W2060678694 @default.
• W2035009609 cites W2071793778 @default.
• W2035009609 cites W2075723991 @default.
• W2035009609 cites W2078625115 @default.
• W2035009609 cites W2083659732 @default.
• W2035009609 cites W2089618896 @default.
• W2035009609 cites W2093518775 @default.
• W2035009609 cites W2110182057 @default.
• W2035009609 cites W2128651724 @default.
• W2035009609 cites W2137788779 @default.
• W2035009609 cites W2157222302 @default.
• W2035009609 cites W2162804111 @default.
• W2035009609 cites W2167866149 @default.
• W2035009609 cites W2254650020 @default.
• W2035009609 cites W2265726164 @default.
• W2035009609 cites W2316110478 @default.
• W2035009609 cites W2341398312 @default.
• W2035009609 cites W2408939907 @default.
• W2035009609 doi "https://doi.org/10.2310/6650.2007.00013" @default.
• W2035009609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17963680" @default.
• W2035009609 hasPublicationYear "2007" @default.
• W2035009609 type Work @default.
• W2035009609 sameAs 2035009609 @default.
• W2035009609 citedByCount "13" @default.
• W2035009609 countsByYear W20350096092012 @default.
• W2035009609 countsByYear W20350096092013 @default.
• W2035009609 countsByYear W20350096092014 @default.
• W2035009609 countsByYear W20350096092016 @default.
• W2035009609 countsByYear W20350096092017 @default.
• W2035009609 crossrefType "journal-article" @default.
• W2035009609 hasAuthorship W2035009609A5000900815 @default.
• W2035009609 hasAuthorship W2035009609A5003396372 @default.
• W2035009609 hasAuthorship W2035009609A5017439924 @default.
• W2035009609 hasAuthorship W2035009609A5031080698 @default.
• W2035009609 hasAuthorship W2035009609A5035254382 @default.
• W2035009609 hasAuthorship W2035009609A5053048440 @default.
• W2035009609 hasAuthorship W2035009609A5062212384 @default.
• W2035009609 hasAuthorship W2035009609A5075655406 @default.
• W2035009609 hasConcept C126322002 @default.
• W2035009609 hasConcept C134018914 @default.
• W2035009609 hasConcept C144980905 @default.
• W2035009609 hasConcept C149601957 @default.
• W2035009609 hasConcept C150903083 @default.
• W2035009609 hasConcept C170493617 @default.
• W2035009609 hasConcept C181199279 @default.
• W2035009609 hasConcept C185592680 @default.
• W2035009609 hasConcept C202751555 @default.
• W2035009609 hasConcept C207001950 @default.
• W2035009609 hasConcept C26291073 @default.
• W2035009609 hasConcept C2775838275 @default.
• W2035009609 hasConcept C2776151105 @default.
• W2035009609 hasConcept C2778102346 @default.
• W2035009609 hasConcept C2778979269 @default.
• W2035009609 hasConcept C2779719074 @default.
• W2035009609 hasConcept C2780795997 @default.
• W2035009609 hasConcept C2908929049 @default.
• W2035009609 hasConcept C55493867 @default.
• W2035009609 hasConcept C71924100 @default.
• W2035009609 hasConcept C86803240 @default.
• W2035009609 hasConcept C98274493 @default.
• W2035009609 hasConceptScore W2035009609C126322002 @default.
• W2035009609 hasConceptScore W2035009609C134018914 @default.
• W2035009609 hasConceptScore W2035009609C144980905 @default.
• W2035009609 hasConceptScore W2035009609C149601957 @default.
• W2035009609 hasConceptScore W2035009609C150903083 @default.
• W2035009609 hasConceptScore W2035009609C170493617 @default.
• W2035009609 hasConceptScore W2035009609C181199279 @default.
• W2035009609 hasConceptScore W2035009609C185592680 @default.
• W2035009609 hasConceptScore W2035009609C202751555 @default.
• W2035009609 hasConceptScore W2035009609C207001950 @default.
• W2035009609 hasConceptScore W2035009609C26291073 @default.
• W2035009609 hasConceptScore W2035009609C2775838275 @default.
• W2035009609 hasConceptScore W2035009609C2776151105 @default.

• next