Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035019335> ?p ?o ?g. }
- W2035019335 endingPage "390" @default.
- W2035019335 startingPage "386" @default.
- W2035019335 abstract "Alismatis rhizoma or Alisma orientale (Zexie in Chinese), the dried rhizome of Alisma orientale Juzepzuk (Alismataceae), is a well-known traditional Chinese medicine and is used as an agent for diuresis and for excreting dampness in Asia and Europe. In this paper, we report the diuretic activities of the ethanol extract (EE) and the aqueous extract (AE) of A. rhizoma (AR). The EE and AE were orally administered to rats. The urinary excretion rate and pH, and electrolyte excretion were measured in the urine of saline-loaded rats. The results showed that EE could increase the urine output at 2.5, 5 and 10 mg/kg doses but decrease the urine output at 20, 40 and 80 mg/kg doses compared with the control group. The 5 and 10 mg/kg doses of EE increased the urine electrolyte excretion, but the effects on Na+/K+ values were too weak to reach statistical significance. The Na+ excretion and Cl− excretion were markedly decreased with the 20, 40 and 80 mg/kg doses of EE, but the effect on K+ excretion was notably slight. All of the tested doses of AE produced an increase in urinary excretion, but the increase did not reach statistical significance. This study identified that EE but not AE presents a notable diuretic effect, and EE had diuretic and anti-diuretic effects, which appears to be related to the sodium–chloride co-transporter in the renal distal convoluting tubule. This study demonstrated for the first time that the EE of AR has a dual effect on renal function, including promotion of diuretic activity at lower doses and inhibiting diuretic activity at higher doses, and the AR dose should be given more attention in clinical applications. This study will play a critical and guiding role in the dosing of AR as a diuretic drug in clinical applications." @default.
- W2035019335 created "2016-06-24" @default.
- W2035019335 creator A5025292310 @default.
- W2035019335 creator A5037571653 @default.
- W2035019335 creator A5038798689 @default.
- W2035019335 creator A5043016170 @default.
- W2035019335 creator A5075079353 @default.
- W2035019335 creator A5088303852 @default.
- W2035019335 date "2014-06-01" @default.
- W2035019335 modified "2023-10-18" @default.
- W2035019335 title "Diuretic and anti-diuretic activities of the ethanol and aqueous extracts of Alismatis rhizoma" @default.
- W2035019335 cites W129743679 @default.
- W2035019335 cites W1489083887 @default.
- W2035019335 cites W1493096137 @default.
- W2035019335 cites W1970903571 @default.
- W2035019335 cites W1978620738 @default.
- W2035019335 cites W1981058689 @default.
- W2035019335 cites W1990051280 @default.
- W2035019335 cites W2005128747 @default.
- W2035019335 cites W2006568470 @default.
- W2035019335 cites W2011452009 @default.
- W2035019335 cites W2029497311 @default.
- W2035019335 cites W2065300687 @default.
- W2035019335 cites W2067122594 @default.
- W2035019335 cites W2067218262 @default.
- W2035019335 cites W2087660547 @default.
- W2035019335 cites W2087919146 @default.
- W2035019335 cites W2094199236 @default.
- W2035019335 cites W2136458474 @default.
- W2035019335 cites W2317743820 @default.
- W2035019335 cites W2411698810 @default.
- W2035019335 cites W2949730651 @default.
- W2035019335 cites W4254785972 @default.
- W2035019335 doi "https://doi.org/10.1016/j.jep.2014.04.017" @default.
- W2035019335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24746479" @default.
- W2035019335 hasPublicationYear "2014" @default.
- W2035019335 type Work @default.
- W2035019335 sameAs 2035019335 @default.
- W2035019335 citedByCount "56" @default.
- W2035019335 countsByYear W20350193352014 @default.
- W2035019335 countsByYear W20350193352015 @default.
- W2035019335 countsByYear W20350193352016 @default.
- W2035019335 countsByYear W20350193352017 @default.
- W2035019335 countsByYear W20350193352018 @default.
- W2035019335 countsByYear W20350193352019 @default.
- W2035019335 countsByYear W20350193352020 @default.
- W2035019335 countsByYear W20350193352021 @default.
- W2035019335 countsByYear W20350193352022 @default.
- W2035019335 countsByYear W20350193352023 @default.
- W2035019335 crossrefType "journal-article" @default.
- W2035019335 hasAuthorship W2035019335A5025292310 @default.
- W2035019335 hasAuthorship W2035019335A5037571653 @default.
- W2035019335 hasAuthorship W2035019335A5038798689 @default.
- W2035019335 hasAuthorship W2035019335A5043016170 @default.
- W2035019335 hasAuthorship W2035019335A5075079353 @default.
- W2035019335 hasAuthorship W2035019335A5088303852 @default.
- W2035019335 hasConcept C10146269 @default.
- W2035019335 hasConcept C134018914 @default.
- W2035019335 hasConcept C159641895 @default.
- W2035019335 hasConcept C178790620 @default.
- W2035019335 hasConcept C185592680 @default.
- W2035019335 hasConcept C2779547328 @default.
- W2035019335 hasConcept C2779918671 @default.
- W2035019335 hasConcept C2780026642 @default.
- W2035019335 hasConcept C537181965 @default.
- W2035019335 hasConcept C55493867 @default.
- W2035019335 hasConcept C556039675 @default.
- W2035019335 hasConcept C71924100 @default.
- W2035019335 hasConcept C98274493 @default.
- W2035019335 hasConceptScore W2035019335C10146269 @default.
- W2035019335 hasConceptScore W2035019335C134018914 @default.
- W2035019335 hasConceptScore W2035019335C159641895 @default.
- W2035019335 hasConceptScore W2035019335C178790620 @default.
- W2035019335 hasConceptScore W2035019335C185592680 @default.
- W2035019335 hasConceptScore W2035019335C2779547328 @default.
- W2035019335 hasConceptScore W2035019335C2779918671 @default.
- W2035019335 hasConceptScore W2035019335C2780026642 @default.
- W2035019335 hasConceptScore W2035019335C537181965 @default.
- W2035019335 hasConceptScore W2035019335C55493867 @default.
- W2035019335 hasConceptScore W2035019335C556039675 @default.
- W2035019335 hasConceptScore W2035019335C71924100 @default.
- W2035019335 hasConceptScore W2035019335C98274493 @default.
- W2035019335 hasIssue "2" @default.
- W2035019335 hasLocation W20350193351 @default.
- W2035019335 hasLocation W20350193352 @default.
- W2035019335 hasOpenAccess W2035019335 @default.
- W2035019335 hasPrimaryLocation W20350193351 @default.
- W2035019335 hasRelatedWork W1975157971 @default.
- W2035019335 hasRelatedWork W2083400764 @default.
- W2035019335 hasRelatedWork W2122514657 @default.
- W2035019335 hasRelatedWork W2252560886 @default.
- W2035019335 hasRelatedWork W2324387328 @default.
- W2035019335 hasRelatedWork W2338093981 @default.
- W2035019335 hasRelatedWork W2415807321 @default.
- W2035019335 hasRelatedWork W2744822199 @default.
- W2035019335 hasRelatedWork W3097664100 @default.
- W2035019335 hasRelatedWork W2340861862 @default.
- W2035019335 hasVolume "154" @default.