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• W2035030010 abstract "We describe a novel synthetic small molecule which shows an unprecedented stabilization of the human telomeric G-quadruplex with high selectivity relative to double-stranded DNA. We report that this compound can be used in vitro to inhibit telomerase activity and to uncap human POT1 (protection of telomeres 1) from the telomeric G-overhang. We also show that the small molecule G-quadruplex binder induces a partial alteration of shelterin through POT1 uncapping from telomeres in human HT1080 cancer cells and the presence of gammaH2AX foci colocalized at telomeres." @default.
• W2035030010 created "2016-06-24" @default.
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• W2035030010 date "2008-11-01" @default.
• W2035030010 modified "2023-10-04" @default.
• W2035030010 title "A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres" @default.
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• W2035030010 doi "https://doi.org/10.1021/ja805615w" @default.
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