Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035034617> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2035034617 endingPage "667" @default.
- W2035034617 startingPage "663" @default.
- W2035034617 abstract "Tumor necrosis factor (TNF)-inducing, mitogenic, polyclonal B cell activation (PBA), macrophage activation and antiviral activities of chemically synthesized lipid A-subunit analogues, GLA-27 and GLA-40, were investigated. The structure of GLA-27 comprises 4-O-phosphono-D-glucosamine carrying tetradecanoyl and 3-tetradecanoyloxytetradecanoyl [C14-O-(C14)] groups as the 3-O- and 2-N-acyl substituents, respectively. GLA-40 is a 1-deoxy compound of GLA-27. The activities of stereoisomers, (R) and (S) forms at the C3 position of the C14-O-(C14) group, of both compounds were also investigated. TNF-inducing activity of the (S) isomers of GLA-27 and GLA-40 was stronger than that of the (R) isomers while the (R) isomers exhibited stronger mitogenic and PBA activities than the (S) isomers. With respect to macrophage activation such as phagocytosis, acid phosphatase and N-acetyl-beta-D-glucosaminidase activity as cellular lysosomal enzymes and cytostasis, peritoneal macrophages obtained from mice administered i.p. with test samples showed significant activities. Among stereoisomers of GLA-27, the (R) isomer exhibited somewhat stronger phagocytic and lysosomal enzyme activities than those of the (S) isomer while there was no appreciable difference in the activities between the isomers of GLA-40. Significant cytostasis-inducing activity was observed in stereoisomers tested. All of the isomers showed remarkable antiviral activity against vaccinia virus." @default.
- W2035034617 created "2016-06-24" @default.
- W2035034617 creator A5000858863 @default.
- W2035034617 creator A5003674139 @default.
- W2035034617 creator A5017456486 @default.
- W2035034617 creator A5035494664 @default.
- W2035034617 creator A5036518400 @default.
- W2035034617 creator A5049790023 @default.
- W2035034617 creator A5062148063 @default.
- W2035034617 creator A5085160955 @default.
- W2035034617 creator A5087958783 @default.
- W2035034617 date "1987-01-01" @default.
- W2035034617 modified "2023-10-14" @default.
- W2035034617 title "Effect of stereospecificity of chemically synthesized lipid A-subunit analogues GLA-27 and GLA-40 on the expression of immunopharmacological activities" @default.
- W2035034617 cites W1547634707 @default.
- W2035034617 cites W1964532737 @default.
- W2035034617 cites W1969862276 @default.
- W2035034617 cites W1986969980 @default.
- W2035034617 cites W2008084002 @default.
- W2035034617 cites W2039292594 @default.
- W2035034617 cites W2040771394 @default.
- W2035034617 cites W2046368149 @default.
- W2035034617 cites W2065481435 @default.
- W2035034617 cites W2073242046 @default.
- W2035034617 cites W2083592165 @default.
- W2035034617 cites W2126356011 @default.
- W2035034617 cites W2132994552 @default.
- W2035034617 cites W2167714489 @default.
- W2035034617 cites W2328577316 @default.
- W2035034617 cites W331322873 @default.
- W2035034617 cites W4242863620 @default.
- W2035034617 cites W4313315044 @default.
- W2035034617 doi "https://doi.org/10.1002/eji.1830170513" @default.
- W2035034617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3495442" @default.
- W2035034617 hasPublicationYear "1987" @default.
- W2035034617 type Work @default.
- W2035034617 sameAs 2035034617 @default.
- W2035034617 citedByCount "32" @default.
- W2035034617 crossrefType "journal-article" @default.
- W2035034617 hasAuthorship W2035034617A5000858863 @default.
- W2035034617 hasAuthorship W2035034617A5003674139 @default.
- W2035034617 hasAuthorship W2035034617A5017456486 @default.
- W2035034617 hasAuthorship W2035034617A5035494664 @default.
- W2035034617 hasAuthorship W2035034617A5036518400 @default.
- W2035034617 hasAuthorship W2035034617A5049790023 @default.
- W2035034617 hasAuthorship W2035034617A5062148063 @default.
- W2035034617 hasAuthorship W2035034617A5085160955 @default.
- W2035034617 hasAuthorship W2035034617A5087958783 @default.
- W2035034617 hasConcept C104292427 @default.
- W2035034617 hasConcept C104317684 @default.
- W2035034617 hasConcept C109316439 @default.
- W2035034617 hasConcept C144464004 @default.
- W2035034617 hasConcept C161790260 @default.
- W2035034617 hasConcept C181199279 @default.
- W2035034617 hasConcept C182547069 @default.
- W2035034617 hasConcept C185592680 @default.
- W2035034617 hasConcept C187921627 @default.
- W2035034617 hasConcept C202751555 @default.
- W2035034617 hasConcept C203014093 @default.
- W2035034617 hasConcept C2778754761 @default.
- W2035034617 hasConcept C55493867 @default.
- W2035034617 hasConcept C71240020 @default.
- W2035034617 hasConcept C86803240 @default.
- W2035034617 hasConceptScore W2035034617C104292427 @default.
- W2035034617 hasConceptScore W2035034617C104317684 @default.
- W2035034617 hasConceptScore W2035034617C109316439 @default.
- W2035034617 hasConceptScore W2035034617C144464004 @default.
- W2035034617 hasConceptScore W2035034617C161790260 @default.
- W2035034617 hasConceptScore W2035034617C181199279 @default.
- W2035034617 hasConceptScore W2035034617C182547069 @default.
- W2035034617 hasConceptScore W2035034617C185592680 @default.
- W2035034617 hasConceptScore W2035034617C187921627 @default.
- W2035034617 hasConceptScore W2035034617C202751555 @default.
- W2035034617 hasConceptScore W2035034617C203014093 @default.
- W2035034617 hasConceptScore W2035034617C2778754761 @default.
- W2035034617 hasConceptScore W2035034617C55493867 @default.
- W2035034617 hasConceptScore W2035034617C71240020 @default.
- W2035034617 hasConceptScore W2035034617C86803240 @default.
- W2035034617 hasIssue "5" @default.
- W2035034617 hasLocation W20350346171 @default.
- W2035034617 hasLocation W20350346172 @default.
- W2035034617 hasOpenAccess W2035034617 @default.
- W2035034617 hasPrimaryLocation W20350346171 @default.
- W2035034617 hasRelatedWork W1550996414 @default.
- W2035034617 hasRelatedWork W2022737265 @default.
- W2035034617 hasRelatedWork W2116993946 @default.
- W2035034617 hasRelatedWork W2402700063 @default.
- W2035034617 hasRelatedWork W2439449588 @default.
- W2035034617 hasRelatedWork W2950003725 @default.
- W2035034617 hasRelatedWork W2950052347 @default.
- W2035034617 hasRelatedWork W2950284807 @default.
- W2035034617 hasRelatedWork W2952795821 @default.
- W2035034617 hasRelatedWork W2998463264 @default.
- W2035034617 hasVolume "17" @default.
- W2035034617 isParatext "false" @default.
- W2035034617 isRetracted "false" @default.
- W2035034617 magId "2035034617" @default.
- W2035034617 workType "article" @default.